Name | 2,5-Difluoropyridine |
Synonyms | 2,5-Difluorpyridin 2,5-Difluoropyridine 2,5-DIFLUOROPYRIDINE Pyridine,2,5-difluoro- Pyridine, 2,5-difluoro- 2,5- twofluorine pyridine |
CAS | 84476-99-3 |
InChI | InChI=1/C5H3F2N/c6-4-1-2-5(7)8-3-4/h1-3H |
InChIKey | XFAMUOYNXFXQTC-UHFFFAOYSA-N |
Molecular Formula | C5H3F2N |
Molar Mass | 115.08 |
Density | 1.274 g/mL at 25 °C |
Melting Point | -33°C(lit.) |
Boling Point | 115°C(lit.) |
Flash Point | 24℃ |
Vapor Presure | 24.9mmHg at 25°C |
pKa | -2.85±0.10(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
Refractive Index | 1.4440 |
Physical and Chemical Properties | Colorless transparent liquid |
Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37 - Wear suitable gloves. |
UN IDs | 1993 |
WGK Germany | 3 |
HS Code | 29333990 |
Hazard Class | IRRITANT, FLAMMABLE |
Packing Group | Ⅲ |
application | 2,5-difluoropyridine is the starting material for many drug synthesis, especially many important intermediates of pyridine compounds. For example, 2, 5-difluoropyridine can be used to synthesize 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4-hydro-quinazine-3-carboxylate, 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4-hydro-quinazine-3-carboxylate is an important intermediate of a class of antibacterial drugs. |
use | 2,5-difluoropyridine is a pyridine derivative, mainly used as a pharmaceutical intermediate. |
preparation | using 2,5-dichloropyridine as raw material, 2,5-dibromopyridine is prepared by halogenation method, and then further methylation can obtain the product 2,5-difluoropyridine we want. The purity of this crude product can meet the general reaction requirements and can be directly put into application. |
chemical properties | colorless transparent liquid |