836615-83-9 - Names and Identifiers
836615-83-9 - Physico-chemical Properties
Molecular Formula | C13H10BF3O3
|
Molar Mass | 282.02 |
Density | 1.38±0.1 g/cm3(Predicted) |
Melting Point | 120-124°C |
Boling Point | 439.1±55.0 °C(Predicted) |
Flash Point | 219.4°C |
Vapor Presure | 1.74E-08mmHg at 25°C |
pKa | 7.61±0.58(Predicted) |
Refractive Index | 1.548 |
836615-83-9 - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
|
WGK Germany | 3 |
836615-83-9 - Introduction
{2,6-difluoro-3-[(2-fluorobenzyl)oxy]phenyl}boronic acid is an organic compound. The following is information about its nature, use, formulation and safety:
Nature:
-Appearance: solid, common for white crystal or white powder.
-Molecular formula: C12H9BF3O2
-Molecular Weight: 260.01 grams/mol
-Melting point: approximately 126-130°C
-Solubility: Soluble in many organic solvents, such as ethanol, dimethyl sulfoxide
Use:
{2,6-difluoro-3-[(2-fluorobenzyl)oxy]phenyl}boronic acid is widely used as an important reagent in organic synthesis, and is commonly used in the synthesis and chemical reaction of phenylboronic acid compounds. It can be used as a precise substitution reagent for aromatic compounds, participating in double bond formation, reduction and oxidation reactions.
Preparation Method:
The {2,6-difluoro-3-[(2-fluorobenzyl)oxy]phenyl}boronic acid can be synthesized by the following steps:
1. 2-Fluorobenzyl alcohol and 2,6-difluorobenzeneborate are reacted in the presence of a base.
2. The reaction mixture is hydrolyzed to produce the target product {2,6-difluoro-3-[(2-fluorobenzyl)oxy]phenyl}boronic acid.
Safety Information:
No detailed laboratory data have been reported regarding the safety and toxicity of {2,6-difluoro-3-[(2-fluorobenzyl)oxy]phenyl}boronic acid. However, in general, it is recommended to take necessary laboratory safety measures to avoid inhalation, ingestion or contact with skin and eyes. Please refer to the relevant safety technical information and operating procedures for specific use.
Last Update:2024-04-10 22:29:15