Name | Cabergoline |
Synonyms | C08187 Cabaser Dostine Dostinex FCE-21336 CABERGOLINE Cabergoline (8-beta)-(2-propenyl) FCE-21336,Cabaser,Dostinex n-(3-(dimethylamino)propyl)-n-((ethylamino)carbonyl)-6-ergoline-8-carboxamid 6-allyl-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)ergoline-8-carboxamide (8β,10ξ)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-prop-2-en-1-ylergoline-8-carboxamide (8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide (8b)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)- ergoline-8-carboxamide |
CAS | 81409-90-7 |
EINECS | 200-419-0 |
InChI | InChI=1/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21?,23-/m1/s1 |
InChIKey | KORNTPPJEAJQIU-KJXAQDMKSA-N |
Molecular Formula | C26H37N5O2 |
Molar Mass | 451.6 |
Density | 1.156±0.06 g/cm3(Predicted) |
Melting Point | 102-104°C |
Solubility | DMSO: ≥10mg/mL |
Appearance | powder |
Color | White to Off-White |
pKa | 13.05±0.46(Predicted) |
Storage Condition | 2-8°C |
Stability | Hygroscopic |
Refractive Index | 1.594 |
Physical and Chemical Properties | white crystals were obtained from diethyl ether, melting point 102-104 °c. Acute toxicity LD50 mice (mg/kg):>400 oral. |
Use | Long-acting dopamine antagonists. For the treatment of primary or pituitary adenoma caused by high prolactin. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
WGK Germany | 3 |
RTECS | KE6167600 |
HS Code | 2939690000 |
Toxicity | Sol in ethyl alcohol, chloroform, DMF; slightly sol in 0.1 N HCl; very slightly sol in n-hexane. Insol in water. LD50 orally in male mice: >400 mg/kg (Brambilla) |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.214 ml | 11.072 ml | 22.143 ml |
5 mM | 0.443 ml | 2.214 ml | 4.429 ml |
10 mM | 0.221 ml | 1.107 ml | 2.214 ml |
5 mM | 0.044 ml | 0.221 ml | 0.443 ml |