800402-07-7 - Names and Identifiers
Name | 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid
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Synonyms | 6-chloro-1H-pyrrolo[2 2-Carboxy-6-chloro-1H-pyrrolo[2,3-b]pyridine 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 6-Chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-chloro- acide 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylique
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CAS | 800402-07-7
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InChI | InChI=1/C8H5ClN2O2/c9-6-2-1-4-3-5(8(12)13)10-7(4)11-6/h1-3H,(H,10,11)(H,12,13) |
800402-07-7 - Physico-chemical Properties
Molecular Formula | C8H5ClN2O2
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Molar Mass | 196.59 |
Density | 1.644±0.06 g/cm3(Predicted) |
Boling Point | 467.036°C at 760 mmHg |
Flash Point | 236.255°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 3.88±0.30(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.744 |
800402-07-7 - Introduction
6-chloro-1H-pyrrolidone [2,3-b]pyridine-2-carboxylic acid is an organic compound whose chemical formula is C10H5ClN2O2. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid is a white solid.
-Solubility: It dissolves in some organic solvents, such as dimethyl sulfoxide (DMSO),N,N-dimethylformamide (DMF), etc.
Use:
- 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid is often used as an important intermediate in drug synthesis.
-It is widely used to develop biologically active compounds, such as anti-tumor and antiviral drugs.
Preparation Method:
The preparation method of 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid can be carried out by the following steps:
1. 2-Fluoro-3-chloropyridine is reacted with ruthenium catalyst to obtain the corresponding 2,3-dichloropyridine derivative.
2. reacting 2,3-dichloropyridine with an appropriate amount of sodium hydroxide (NaOH) to obtain the corresponding 2-chloropyrrolo [2,3-B] pyridine derivative.
3. Finally, 2-chloropyrrolo [2,3-B] pyridine derivatives can be hydrolyzed under acidic conditions to obtain the target product, namely 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid.
Safety Information:
- 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid may be potentially harmful to the environment and should be disposed of properly.
-During use, you must follow the laboratory's safety procedures and wear appropriate personal protective equipment, such as gloves, glasses and laboratory coats.
-Avoid direct contact with skin and eyes, and maintain a well-ventilated working environment.
-In case of skin contact or ingestion, rinse immediately with water and seek medical help.
Last Update:2024-04-09 21:00:56