Name | Homatropine Methylbromide |
Synonyms | ESOPIN HOMOLONE ARKITROPIN homatropine methobromide Homatropine Methylbromide Homatropine methyl bromide HOMATROPINE METHYL BROMIDE dl-homatropine methyl bromide 8-METHYLHOMATROPINIUM BROMIDE DL-HOMATROPINE METHYL BROMIDE N-METHYLHOMATROPINIUM BROMIDE N-methylhomatropinium bromide TROPINIUM METHOBROMIDE MANDELATE (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl hydroxy(phenyl)acetate 3-{[hydroxy(phenyl)acetyl]oxy}-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide |
CAS | 80-49-9 |
EINECS | 201-284-0 |
InChI | InChI=1/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3/t12-,13+,14+,15? |
Molecular Formula | C17H24BrNO3 |
Molar Mass | 370.28 |
Density | 1.21g/cm3 |
Melting Point | 192°C |
Boling Point | 403.3°C at 760 mmHg |
Flash Point | 197.7°C |
Solubility | Freely soluble in water, soluble in ethanol 96 per cent |
Vapor Presure | 3.15E-07mmHg at 25°C |
Appearance | neat |
Color | White to Off-White |
Merck | 14,4730 |
Storage Condition | -20°C Freezer |
Refractive Index | 1.588 |
In vitro study | Homatropine (20 μm) alone produced 259 dose ratios in guinea pig atria. The combination of Homatropine (20 μm) with hexamethonium produced only 95.0 dose ratios in guinea pig atria. Homatropine has a similar affinity for muscarinic receptors in the stomach (pA2 = 7.13) and modulates the power (pA2 = 7.21) and ratio (pA2 = 7.07) responses in the atria. sup> [3] |
In vivo study | Homatropine (20 mg/kg) protected rats from dichlorvos intoxication with a survival rate of 30% and a time to death ranging from 4 to 12 minutes, while Homatropine (10 mg/kg) it has no effect on preventing death. In rats, Homatropine [ |
Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
UN IDs | 1544 |
WGK Germany | 3 |
RTECS | MS9000000 |
HS Code | 29399990 |
Hazard Class | 6.1 |
Packing Group | III |
Toxicity | LD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede) |