Name | 4-Aminophenyl sulfone |
Synonyms | DDS EPORAL Dapsone 4,4'-DDS DISULONE NOVOPHONE AVLOSULFON SULFONA-MAE SULPHADIONE TIMTEC-BB SBB003168 4-Aminophenyl sulfone P-AMINOPHENYL SULFONE 4,4-Sulfonyldianiline diaminodiphenylsulfone P,P'-SULFONYLDIANILINE 4,4-sulphonyldianiline 4-Aminophenyl sulphone BIS(P-AMINOPHENYL)SULFONE BIS(4-AMINOPHENYL) SULFONE di(4-aminophenyl) sulphone 4,4'-Diaminodiphenylsulfone 4,4-Diaminodiphenyl sulfone 4,4-Diaminodiphenyl sulphone 4,4'-Diamino Diphenyl Sulfone 4,4'-Diaminodiphenyl sulphone 4,4'-Diamino Diphenyl Sulphone 4-((4-aminophenyl)sulfonyl)phenylamine 4,4'-Diaminodiphenyl sulfone for synthesis FREE SAMPLE NCV 4,4-DIAMINO DIPHENYL SULPHONE STD |
CAS | 80-08-0 |
EINECS | 201-248-4 |
InChI | InChI=1/C12H10O2S.C7H6N2O5/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12;1-4-2-5(8(11)12)3-6(7(4)10)9(13)14/h1-10H;2-3,10H,1H3 |
InChIKey | MQJKPEGWNLWLTK-UHFFFAOYSA-N |
Molecular Formula | C12H12N2O2S |
Molar Mass | 248.3 |
Density | 1.2701 (rough estimate) |
Melting Point | 175-177°C(lit.) |
Boling Point | 511.7±35.0 °C(Predicted) |
Water Solubility | <0.1 g/100 mL at 20 ºC |
Solubility | 0.38g/l |
Vapor Presure | 0.004Pa at 25℃ |
Appearance | Crystalline Powder |
Color | White to beige |
Merck | 14,2822 |
BRN | 788055 |
pKa | pKb 13.0(at 25℃) |
PH | 5.5-7.5 (H2O, 20℃)(saturated aqueous solution) |
Storage Condition | 2-8°C |
Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Refractive Index | 1.5950 (estimate) |
Physical and Chemical Properties | Melting point 173-178°C water-soluble <0.1g/100 mL at 20°C |
Use | The drug of choice for the treatment of leprosy, can also be combined with other anti-leprosy drugs |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
Safety Description | 22 - Do not breathe dust. |
UN IDs | 3249 |
WGK Germany | 1 |
RTECS | BY8925000 |
TSCA | Yes |
HS Code | 29309070 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 orally in Rabbit: 1000 mg/kg LD50 dermal Rabbit > 4000 mg/kg |
This product is 4,4 '-sulfonyl bis-aniline. Calculated as the dried product, the content of C12H12N202S shall not be less than 99.0%.
The melting point of this product (General 0612) is 176~181°C.
take this product, add methanol to dissolve and dilute to make a solution containing about 10 mg per 1 ml, as a test solution; Take appropriate amount of precision, solutions containing about 20UG and 100ug per 1 ml, respectively, were prepared by dilution with methanol as Control Solutions (1) and (2). According to the thin layer chromatography (General 0502) test, draw 10ul of each of the above three solutions, respectively, on the same silica gel G thin layer plate, with toluene-acetone (2:1) as the developing solvent, dry, spray with 0.5% sodium nitrite 0. A 1 mol/L hydrochloric acid solution was then sprayed with a 0.1% dihydrochloric acid solution of naphthyl ethylenediamine after several minutes. Test solution such as impurity spots, compared with the control solution (1) of the main spot, not deeper; If there is more than 1~2 points, should not be deep in the control solution (2) the main spot.
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
take this product about 0.25g, precision weighing, add water 30ml and hydrochloric acid solution (l-2)20ml, according to the permanent stop titration method (General rule 0701), with sodium nitrite titration solution (0.lmol/L) titration. Each l of sodium nitrite titration solution (0.1 mol/L) corresponds to 12.42mg of C12H12N202S.
anti-leprosy drugs.
sealed storage.
This product contains dapsone (C12H12N202S) should be 93.0% to 107.0% of the label.
This product is white or off-white.
Take 20 tablets of this product, precise weighing, fine grinding, precise weighing to take an appropriate amount (equivalent to dapsone 0.25g), according to the method under the dapsone determination. Each 1 ml of sodium nitrite titration solution (0.1 mol/L) corresponds to 12.42mg of C12H12N202S.
Same as dapsone.
(l)50mg (2)100mg
sealed storage.