8-Phenethyl-1-oxa-3,8-diazaspiro(4.5)decan-2-one monohydrochloride
Fenspiride hydrochloride
CAS: 5053-08-7
Molecular Formula: C15H21ClN2O2
8-Phenethyl-1-oxa-3,8-diazaspiro(4.5)decan-2-one monohydrochloride - Names and Identifiers
8-Phenethyl-1-oxa-3,8-diazaspiro(4.5)decan-2-one monohydrochloride - Physico-chemical Properties
| Molecular Formula | C15H21ClN2O2 |
| Molar Mass | 296.79 |
| Melting Point | 235-238°C (dec.) |
| Boling Point | 474.3°C at 760 mmHg |
| Flash Point | 240.6°C |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Vapor Presure | 3.67E-09mmHg at 25°C |
| Appearance | powder |
| Color | white |
| Storage Condition | Refrigerator |
| In vitro study | Fenspiride acts on isolated human bronchi and induces the potentiating effects of isoproterenol and sodium nitropronate with logEC50 of 4.1 and 3.5, respectively. |
| In vivo study | Fenspiride, an anti-inflammatory agent with low anti-cyclooxygenase activity, was administered orally to rats at a dose of 60-200 mg/kg, inhibits Endotoxin-induced but not Carrageenin-induced neutrophil migration into the peritoneal cavity and exudation into the peritoneal cavity. Treatment of rats with Fenspiride (200 mg/kg) inhibited the release of tumor necrosis factor by stimulating macrophages in a dose-dependent manner. Treatment of myringotomized rats with Fenspiride (topical application) inhibited the development of sclerosing lesions, while by intraperitoneal injection was ineffective. Treatment of endotoxemic guinea pigs with Fenspiride (60 mg/kg) significantly reduced serum levels (4.2 ng/mL vs. 2.3 ng/mL). And early rise of LPS-induced TNF concentrations in bronchoalveolar lavage fluid (55.7 ng/mL vs. 19.7 ng/mL). Fenspiride (60 mg/kg) also significantly reduced lipopolysaccharide-induced pulmonary Macrophage stimulation after N-formyl-methionyl-phenylalanine stimulation, compared with untreated control cells, enhanced release of arachidonic acid metabolites. Treatment of endotoxemic guinea pigs with Fenspiride (60 mg/kg) reduced elevated serum concentrations of extracellular type II phospholipase A2, the intensity of neutrophil infiltration into the alveoli, and the lethality of lipopolysaccharide. |
8-Phenethyl-1-oxa-3,8-diazaspiro(4.5)decan-2-one monohydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | RO0375000 |
| Toxicity | LD50 i.v. in mice: 106 mg/kg; orally in rats: 437 mg/kg (LeDouarec) |
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View History
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