Name | 8-Hydroxyquinoline |
Synonyms | HQ OQ 8-OQ OXIN Tumex Oxine Fennosan 8-Quinol fennosan 8-Quinolol quinophenol fennosanh30 oxychinolin 8-Quinolinol oxyquinoline phenopyridine Chinolin-8-ol 8-Oxyquinolin Fennosan H 30 Quinolin-8-ol 8-oxyquinoline Quinoleine-8-ol Hydroxychinolin oxybenzopyridine Hydroxyquinoline 8-Hydroxyquinoline 8-hydroxy-quinolin Azanaphthalene-8-ol Hydroxy-8-Quinoline hydroxybenzopyridine |
CAS | 148-24-3 |
EINECS | 205-711-1 |
InChI | InChI=1/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H |
InChIKey | MCJGNVYPOGVAJF-UHFFFAOYSA-N |
Molecular Formula | C9H7NO |
Molar Mass | 145.16 |
Density | 1.0340 |
Melting Point | 70-73°C(lit.) |
Boling Point | 267°C752mm Hg(lit.) |
Flash Point | 267°C |
Water Solubility | INSOLUBLE |
Solubility | Easily soluble in ethanol, acetone, chloroform, benzene and mineral acid, almost insoluble in water |
Vapor Presure | 0.221Pa at 25℃ |
Appearance | White or light yellow crystal or crystalline powder |
Color | White to pale yellow or light beige |
Merck | 14,4843 |
BRN | 114512 |
pKa | 5.017(at 20℃) |
Storage Condition | Store below +30°C. |
Sensitive | Light Sensitive |
Refractive Index | 1.4500 (estimate) |
MDL | MFCD00006807 |
Physical and Chemical Properties | White needle-like crystals. The melting point of 76 deg C, boiling point of 266.6 deg C (100.3kPa). Soluble in ethanol, benzene, chloroform, acetone and dilute acid, insoluble in water. |
Use | The product is an intermediate of halogenated quinoline anti-amoeba drugs, including quiniodoform, chloroiodoquinoline, diiodoquinoline, etc. These drugs play an anti-amoebic effect by inhibiting intestinal commensal bacteria, are effective for amoebic dysentery, and have no effect on extraintestinal amoebic protozoa. In recent years, foreign reports of this class of drugs can cause subacute spinal optic neuropathy, so the drug has been banned in Japan and the United States? |
Risk Codes | R22 - Harmful if swallowed R68 - Possible risk of irreversible effects R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
UN IDs | 2811 |
WGK Germany | 3 |
RTECS | VC4200000 |
TSCA | Yes |
HS Code | 29334990 |
Hazard Note | Harmful/Irritant |
Hazard Class | 9 |
Packing Group | III |
Toxicity | An LD50 value of 1,200mg/kg was reported for oral administration of 8-hydroxyquinoline to rats (straidsex unspecified; AAPCO, 1966);a value of 48 mg/kg was reported for intraperitoneal administration to mice (strain/sex unspecxed; Bernstein et al., 1963). |
white or light yellow crystal or crystalline powder, light black, a smell of carbonic acid. Melting point 76 °c. The boiling point is about 267 °c. Soluble in alcohol, acetone, chloroform, benzene, almost insoluble in water.
O-aminophenol, O-nitrophenol, glycerol, and glacial acetic acid were mixed, concentrated sulfuric acid was added in portions, and the mixture was heated until boiling began. Unreacted O-nitrophenol was then removed by steam distillation at reflux on an oil bath. After cooling, neutralization with sodium hydroxide solution and recovery by steam distillation, 8-Hydroxyquinoline was obtained.
as a complexing agent and extractant for precipitation and separation of metal ions, it can complex with Cu2, Be2, Mg2, Caz, Sr2, Ga3, In3 and other metal ions. Standard for the determination of heterocyclic nitrogen by organic microanalysis, organic synthesis. It is also an intermediate of dyes, pesticides and halogenated quinoline anti-amoeba drugs. Its sulfate and copper salts are excellent preservatives.
mice were injected intraperitoneally with LD50:48mg/kg.