[4-(Trifluoromethyl)pyridine-3-yl]methylamine is an organic compound with the chemical formula C6H6F3N. The following is a description of its nature, use, preparation and safety information:
1. nature:
-Appearance: colorless liquid or white solid;
-Melting point:-2.5°C;
-Boiling point: 147-148°C;
-density: 1.363g/cm³;
-Relative molecular mass: 153.12g/mol.
2. use:
- [4-(Trifluoromethyl)pyridine-3-yl]methylamine is often used as a reagent in organic synthesis;
-It can be used to prepare biologically active compounds, such as drugs and pesticides;
-The compound is used as an intermediate in the chemical industry for the synthesis of other organic compounds.
3. preparation method:
- [4-(Trifluoromethyl)pyridine-3-yl]methylamine can be prepared by various methods, and the following is one of the commonly used methods: First, 4-amino-3-chloropyridine is reacted with trifluoromethyl borate to generate [4-(trifluoromethyl) pyridin-3-yl] methanol, which is then converted into [4-(Trifluoromethyl)pyridine-3-yl]methylamine by dehydration reaction.
4. Safety Information:
- [4-(Trifluoromethyl)pyridine-3-yl]methylamine is irritating and contact with skin, eyes and respiratory tract should be avoided;
-Wear appropriate protective equipment, such as chemical protective gloves, goggles and protective clothing;
-Storage should be sealed and kept away from fire and oxidizing agents.
Please note that proper laboratory practices and safety precautions should be followed when using chemicals.