Name | 4-(N-Methyl-N-benzylamino)piperidine |
Synonyms | N-(2-phenylethyl)-4-piperidinamine N-Benzyl-N-methylpiperidin-4-amine N-benzyl-N-methylpiperidin-4-amine 4-(N-Methyl-N-benzylamino)piperidine N-Methyl-N-benzyl-4-piperidinaMine 2HCl N-benzyl-N-methylpiperidin-4-amine 2HCl 4-(N-METHYL-N-BENZYL)AMINOPIPERIDINE 2HCL N-Methyl-N-(phenylmethyl)-4-piperidinamine |
CAS | 76167-62-9 |
EINECS | 1312995-182-4 |
InChI | InChI=1/C13H20N2/c1-15(13-7-9-14-10-8-13)11-12-5-3-2-4-6-12/h2-6,13-14H,7-11H2,1H3 |
Molecular Formula | C13H20N2 |
Molar Mass | 204.31 |
Density | 1.01±0.1 g/cm3(Predicted) |
Boling Point | 118-120 °C(Press: 0.1 Torr) |
Flash Point | 116.7°C |
Vapor Presure | 0.00109mmHg at 25°C |
pKa | 10.11±0.10(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.555 |
Hazard Class | IRRITANT |
preparation | 4-(N-methyl-N-benzyl) aminopiperidine was prepared as follows: to tert-butyl 4-(N-benzyl-N-methylamino) piperidine -1-carboxylate (1.00g, 3.28mmol) at room temperature 1, to a mixed solution of 4-dioxane/methanol (1/1, 8.0mL) was added a solution of hydrogen chloride in 1, 4-dioxane (4.0N, 3.28mL, 13.1mmol), the reaction solution was stirred at the same temperature for 6 hours. The reaction solution was concentrated under reduced pressure, saturated aqueous sodium bicarbonate solution was added, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, chloroform/methanol) to give 4-(N-methyl-N-benzyl) aminopiperidine (0.650g, 0.318mmol, 97%). |
Application | 4-(N-methyl-N-benzyl) aminopiperidine can be used as a pharmaceutical synthesis intermediate. If inhaling 4-bromoquinoline-6-carboxylic acid, move the patient to fresh air. |