Name | 7-chloro-1H-pyrazolo[3,4-c]pyridine |
Synonyms | o[3,4-c]pyridine 7-chloro-1H-pyrazolo[3 7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE 7-Chloro-1H-pyrazolo[3,4-c]pyridine 7-chloro-1H-pyrazolo[3,4-c]pyridine 1H-Pyrazolo[3,4-c]pyridine, 7-chloro- |
CAS | 76006-11-6 |
InChI | InChI=1/C6H4ClN3/c7-6-5-4(1-2-8-6)3-9-10-5/h1-3H,(H,9,10) |
Molecular Formula | C6H4ClN3 |
Molar Mass | 153.57 |
Density | 1.531 |
Melting Point | 161-163℃ |
Boling Point | 357.485°C at 760 mmHg |
Flash Point | 201.244°C |
Vapor Presure | 0mmHg at 25°C |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.72 |
application | 7-chloro-1H-pyrazolo [3,4-C] pyridine can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in laboratory research and development and chemical production. |
preparation | add 2-chloro -3-amino -4-methyl pyridine (2.3 mmol), ammonia (2.3 mmol), DMSO 3 mL,I 2 0.06g (0.23 mmol), under stirring, the temperature is raised to 80 ℃ ~ 85 ℃ for 30 min ( TLC tracking). After the reaction is over, after cooling to room temperature, add 15 mL absolute ethanol: H 2 O = 1:1 mixed solvent, a large amount of yellow solid is precipitated, stirred for 15 min filtration, and the obtained crude product is directly recrystallized and purified with ethyl acetate to obtain yellow solid pure product with 85% yield. |