754159-68-7 - Names and Identifiers
754159-68-7 - Physico-chemical Properties
Molecular Formula | C29H35NO3
|
Molar Mass | 445.59 |
Density | 1.095 |
754159-68-7 - Introduction
(R)-4-benzyloxy-3-(diisopropylamino-1-phenylpropyl)-benzoic acid hydrochloride, also known as (R)-4-benzyloxy-3-(diisopropylamino-1-phenylpropyl)-benzoic acid hydrochloride, is an organic compound.
Its nature:
-Appearance: White crystalline powder
-Molecular formula: C34H41NO3 · HCl
-Molecular weight: 552.16g/mol
-Melting point: 180-183°C
Its main purpose:
-This compound is often used as a reagent in organic synthesis reactions, especially in chiral synthesis, as a chiral auxiliary reagent or chiral catalyst.
-It is used in the field of medicinal chemistry to synthesize drug molecules, especially anti-inflammatory drugs and neurological drugs.
Preparation Method:
The preparation of (R)-4-benzyloxy-3-(diisopropylamino-1-phenylpropyl)-benzoic acid hydrochloride is generally as follows:
1.3-(diisopropylamino-1-phenylpropyl) benzoic acid and p-toluyl alcohol reaction, under alkaline conditions to add hydrogen bromide and reflux reaction.
2. Add benzyl magnesium bromide to the reaction solution.
3. Acidify using HCl solution and crystallize.
4. Further purification and crystallization gave the final product.
Safety Information:
(R)-4-benzyloxy-3-(diisopropylamino-1-phenylpropyl)-benzoic acid hydrochloride has certain safety risks, and may be harmful to the human body by contact or inhalation. Appropriate laboratory safety measures should be taken during use, including wearing protective gloves and eyes. In addition, store it in a dry, well-ventilated place, away from heat sources and open flames. In case of intentional contact or ingestion, seek medical help immediately.
Last Update:2024-04-09 20:52:54