Molecular Formula | C41H65N13O10 |
Molar Mass | 900.04 |
Density | 1.49±0.1 g/cm3(Predicted) |
pKa | 3.49±0.10(Predicted) |
Storage Condition | −20°C |
MDL | MFCD00076789 |
In vivo study | Substance P (1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (1-7) is an endogenous modulator of SP actions. Injection of low doses of Substance P (1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord. |
WGK Germany | 3 |