Name | 3-Hydroxytyramine hydrochloride |
Synonyms | Dopamine HCL dopaminechloride TIMTEC-BB SBB003668 Dopamine hydrochloride 3-Hydroxytyramine, HCl 3-Hydroxytyramine hydrochloride 3,4-DIHYDROXYPHENETHYLAMINE, HCL OEM 3-Hydroxytyramine hydrochloride 4-(2-aminoethyl)-pyrocatechohydrochloride 3,4-DIHYDROXYPHENETHYLAMINE HYDROCHLORIDE 3,4-Dihydroxyphenethylamine hydrochloride 2-benzenediol,4-(2-aminoethyl)-hydrochloride |
CAS | 62-31-7 |
EINECS | 200-527-8 |
InChI | InChI=1/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H |
InChIKey | CTENFNNZBMHDDG-UHFFFAOYSA-N |
Molecular Formula | C8H12ClNO2 |
Molar Mass | 189.64 |
Density | 1.4 g/cm3 |
Melting Point | 248-250°C(lit.) |
Boling Point | 337.7 °C at 760 mmHg |
Flash Point | 11℃ |
Water Solubility | soluble |
Solubility | Soluble in water, soluble in methanol and hot 95% ethanol, soluble in sodium hydroxide solution, insoluble in ether, chloroform and benzene. |
Appearance | White-like crystal |
Color | light tan |
Merck | 14,8462 |
BRN | 3656720 |
Storage Condition | Store below +30°C. |
Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
Sensitive | Air & Light Sensitive |
MDL | MFCD00012898 |
Physical and Chemical Properties | Melting Point: 241 - 243
|
Use | Dopamine agonist, excites the heart, increases renal blood flow, for hemorrhagic, cardiac and Infective Shock |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 2 |
RTECS | UX1092000 |
FLUKA BRAND F CODES | 8-10-23 |
TSCA | Yes |
HS Code | 29222900 |
Hazard Note | Irritant |
Toxicity | LD50 orally in Rabbit: 2859 mg/kg |
This product is 4-(2-aminoethyl)-1, 2-benzenediol hydrochloride. Calculated as dry product, containing no less than 98.0% of C8H11N02 • HCl.
The pH value of the solution under the items of clarity and color shall be determined according to law (General rule 0631), and the pH value shall be 3.5~5.5.
take 0.10g of this product and add 10ml of freshly boiled cold water to dissolve, the solution should be clear and colorless; If it is colored, it should be compared with the yellow No. 1 Standard Colorimetric solution (General rule 0901 first method), not deeper.
take this product, add mobile phase to dissolve and dilute to make a solution containing about 0.3mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. Appropriate amounts of dopamine hydrochloride reference substance and 4-ethylphthalic acid were dissolved and diluted with mobile phase to prepare a mixed solution containing about 6% of each 1 ml, which was used as a system applicable solution. According to the test of high performance liquid chromatography (General 0512), silica gel bonded with eighteen alkyl silane was used as the filler; Sodium dodecyl sulfate-acetonitrile-glacial acetic acid -0. The mobile phase consisted of 1 mol/L disodium ethylenediamine tetraacetate (700:300:10:2). The detection wavelength was 280nm. The system applicable solution 20 u1 was injected into the liquid chromatograph, and the resolution of dopamine peak and 4-ethylcatechol peak should be greater than 3.0. 20 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
not more than 0.1% (General rule 0841).
take 1.0g of this product, add an appropriate amount of water to dissolve, and check according to law (General rule 0821 first law), containing heavy metals not to exceed 20 parts per million.
take about 0.15g of this product, weigh precisely, add 25ml of glacial acetic acid, boil to dissolve, cool to about 40°C, add 5ml of Mercury acetate test solution, and let cool, add 1 drop of crystal violet indicator solution and use perchloric acid titration solution (0.1 mol/L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Each 1 ml perchloric acid titration solution (0.1 mol/L) corresponds to 18.96mg of C8H11NO2 • HCl.
dopamine receptor agonists.
shading, nitrogen filling, sealed preservation.
This product is a sterile aqueous solution of dopamine hydrochloride. Containing dopamine hydrochloride (C8H11N02 • HCl) shall be between 93.0% and 107.0% of the nominal amount.
This product is a clear colorless liquid.
This product was taken and the same results were shown in the tests of (1), (2) and (4) under the item of dopamine hydrochloride.
Same as dopamine hydrochloride.
2ml:20mg
light shielding, closed storage.