61636-08-6 - Names and Identifiers
Name | 2-Ethoxy-4,6-dihydroxypyrimidine
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Synonyms | 2-Ethoxypyrimidine-4,6-diol 4,6-pyrimidinediol, 2-ethoxy- 2-Ethoxy-4,6-dihydroxypyrimidine 2-ETHOXY-4,6-DIHYDROXYPYRIMIDINE 2-Ethoxy-6-hydroxypyrimidin-4(3H)-one 2-ethoxy-4-hydroxy-1H-pyrimidin-6-one 4(3H)-pyrimidinone, 2-ethoxy-6-hydroxy- 4(3H)-Pyrimidinone, 2-ethoxy-6-hydroxy-
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CAS | 61636-08-6
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InChI | InChI=1/C6H8N2O3/c1-2-11-6-7-4(9)3-5(10)8-6/h3H,2H2,1H3,(H2,7,8,9,10) |
61636-08-6 - Physico-chemical Properties
Molecular Formula | C6H8N2O3
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Molar Mass | 156.14 |
Density | 1.41±0.1 g/cm3(Predicted) |
Melting Point | >318°C |
Boling Point | 384.1°C at 760 mmHg |
Flash Point | 186.1°C |
Vapor Presure | 1.9E-06mmHg at 25°C |
pKa | 4.61±0.10(Predicted) |
Refractive Index | 1.58 |
61636-08-6 - Risk and Safety
Safety Description | S7 - Keep container tightly closed.
S24/25 - Avoid contact with skin and eyes.
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61636-08-6 - Introduction
2-Ethoxy-4, 6-dihydroxyyrimidine is an organic compound with the chemical formula C7H9N3O3. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2-Ethoxy-4, 6-dihydroxyyrimidine is a white crystalline solid.
-Solubility: Its solubility in water is low, but it has better solubility in organic solvents such as ethanol and dimethyl sulfoxide.
-Melting point: Its melting point is about 198-203 degrees Celsius.
Use:
-Pharmaceutical field: 2-Ethoxy-4, 6-dihydroxyyrimidine is an important intermediate that can be used to synthesize some drugs and bioactive molecules.
-Agricultural field: It can also be used as a raw material for pesticides and has a certain killing effect on certain pests.
Preparation Method:
The preparation method of 2-Ethoxy-4,6-dihydroxypyrimidine can be carried out by the following steps:
1. Using 2-methoxy -4,6-dinitropyrimidine as the starting material, the nitro group is reduced to amino group by hydrogenation reduction reaction.
2. Then, ethyl esterification with sodium ethoxide (NaOEt) to generate 2-ethoxy-4, 6-diaminopyrimidine.
3. Finally, the oxidation reaction of 2-ethoxy-4, 6-diaminopyrimidine was carried out under alkaline conditions to generate the target product 2-Ethoxy-4, 6-dihydroxyrimidine.
Safety Information:
2-Ethoxy-4,6-dihydroxypyrimidine has limited toxicity data, but according to relevant information, it is not considered to be more toxic under normal conditions of use. However, safe laboratory procedures must still be followed to prevent contact, inhalation or ingestion. Use appropriate personal protective equipment such as lab gloves, lab glasses, and lab coats when using or handling the compound.
Last Update:2024-04-09 21:00:56