Name | Closantel Sodium |
Synonyms | CLOSANTEL(NA) Closan Sodium Closantel Sodium CLOSANTEL SODIUM closantel sodium salt Closan Sodium (Patented) Closantel Sodium (Patented) Chloride sodium cyanide iodine willow amine Sodium N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-o-tolyl)-2-hydroxy-3,5-diiodobenzamidate n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid sodium salt sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-4,6-diiodophenolate sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodocyclohexa-2,4-diene-1-carboxylate sodium 2-[[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylanilino]-oxomethyl]-1-hydroxy-4,6-diiodo-1-cyclohexa-2,4-dienecarboxylate |
CAS | 61438-64-0 |
EINECS | 262-794-7 |
InChI | InChI=1/C22H14Cl2I2N2O2.Na/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29;/h2-9,17,29H,1H3,(H,28,30);/q;+1/p-1 |
Molecular Formula | C22H13Cl2I2N2NaO2 |
Molar Mass | 685.06 |
Melting Point | >230°C (dec.) |
Boling Point | 590.5°C at 760 mmHg |
Flash Point | 310.9°C |
Vapor Presure | 1.53E-14mmHg at 25°C |
Appearance | Solid |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
MDL | MFCD03427328 |
Use | Used as an antiparasitic agent |
In vitro study | Closantel inhibited drug-resistant Staphylococcus aureus and Enterococcus faecium, MICs 1 μg/mL and 1 μg/mL, respectively. The MRSA MICs inhibited by Closantel was 2 μg/mL. Closantel completely blocks the infection of host cells by E. chaffeensis or A. phagocytophilum, treating in A dose-dependent manner cells persistently infected for one day, thereby clearing the infection. Closantel inhibits the activity of three sensor kinase autokinases from E. chaffeensis. Closantel (50 μg/mL) acts on vascular tissue to induce contractions of greater amplitude and higher frequency than normal. Stimulation at such amplitude and frequency for about 15 minutes is accompanied by an increase in muscle tension, this results in a maximum of 16 min, which is a level greater than 1.5 times the maximum normal amplitude. |
In vivo study | Closantel (10 mg/kg) acted on 25 F before administration. Mice with posterior metacercaria of the hepatica family, after 24 hours, cause total surface damage in mice in the form of erosion of the anterior and posterior limbs of the fluke and extensive molting on the back and abdominal surfaces. Closantel (7.5 mg/kg) in combination with a broad-spectrum anthelmintic was very effective against the nematode twister, but not very effective against the genus Strongylus in sheep. Closantel significantly reduced isotope levels in closantel-resistant, adult sheep infected with the twisted blood spear nematode. |
HS Code | 29269090 |