Name | 2-Amino-5-chlorobenzoxazole |
Synonyms | Zoxine Zoxamin usafma-12 Zoxazolamine ZOXAZOLAMINE TIMTEC-BB SBB003874 2-Amino-5-chlorobenzoxazole 2-AMINO-5-CHLOROBENZOXAZOLE 5-chlorobenzoxazol-2-ylamine 5-chloro-1,3-benzoxazol-2-amine 2-Amino-5-chlorobenzoxazoleZoxazolamine |
CAS | 61-80-3 |
EINECS | 200-519-4 |
InChI | InChI=1/C7H5ClN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10) |
Molecular Formula | C7H5ClN2O |
Molar Mass | 168.58 |
Density | 1.4369 (rough estimate) |
Melting Point | 181-184°C(lit.) |
Boling Point | 316.8±34.0 °C(Predicted) |
Flash Point | 145.4°C |
Solubility | DMSO, Methanol |
Vapor Presure | 0.000401mmHg at 25°C |
Appearance | Powder |
Color | Light brown to yellow-brown |
Merck | 13,10249 |
pKa | 0.73±0.10(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
Refractive Index | 1.5618 (estimate) |
In vitro study | Zoxazolamin is a class of central muscle relaxant drugs that have been reported to act by reducing the activity between central neurons. These drugs, but not the anti-Anxiety drugs, reduce dopamine conversion and induce pacemaker-like firing patterns at dopaminergic neurons. Zoxazolamin belongs to the class of 2-amino -2-oxazoles with biological activity. Zoxazolamin has also been used as a tool to assess hepatocyte cytochrome P-450 activity. |
In vivo study | Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. The time-averaged serum clearance determined from tested concentrations data is 7.22±1.01 mL/min/kg for Zoxazolamine. Infusion of Zoxazolamine to righting reflex (LRR) at three different rates shows increasing Zoxazolamine concentration in serum and brain at the onset of the effect with increasing infusion rates. When the Zoxazolamine infusion is continued for 5 min beyond the onset of LRR, the concentrations of Zoxazolamine in the cerebrospinal fluid (CSF) at the offset of LRR are essentially identical to the onset concentrations. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | DM4550000 |
HS Code | 29349990 |
Toxicity | LD50 in mice, rats (mg/kg): 376, 102 i.p.; 678, 730 orally (Cain, Roszkowski) |