603951-43-5 - Names and Identifiers
Name | 1-(2,4-difluorophenyl)ethanamine
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Synonyms | 1-(2,4-DIFLUOROPHENYL)ETHANAMINE 1-(2,4-difluorophenyl)ethanamine 1-(2',4'-Difluorophenyl)Ethylamine 1-(2',4'-DIFLUOROPHENYL)ETHYLAMINE 2,4-Difluoro-a-methylbenzenemethanamine 2,4-Difluoro-α-MethylbenzeneMethanaMine 2,4-Difluoro-alpha-methyl-benzenmethanamine 2,4-Difluoro-alpha-methylbenzenemethanamine Benzenemethanamine, 2,4-difluoro-.alpha.-methyl- Benzenemethanamine, 2,4-difluoro-alpha-methyl- (9CI)
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CAS | 603951-43-5
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InChI | InChI=1/C8H9F2N/c1-5(11)7-3-2-6(9)4-8(7)10/h2-5H,11H2,1H3 |
603951-43-5 - Physico-chemical Properties
Molecular Formula | C8H9F2N
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Molar Mass | 157.16 |
Density | 1.163±0.06 g/cm3(Predicted) |
Boling Point | 175.4±25.0 °C(Predicted) |
Flash Point | 72.8°C |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 1.15mmHg at 25°C |
Appearance | Oil |
Color | Clear Light Yellow |
pKa | 8.56±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 1.493 |
603951-43-5 - Risk and Safety
Risk Codes | 34 - Causes burns
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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UN IDs | 2735 |
603951-43-5 - Introduction
1-(2,4-difluorophenyl)ethanamine is an organic compound with the chemical formula C8H9F2N. It is an aromatic liquid with a colorless to yellowish appearance. The following is a detailed description of its nature, use, preparation and safety information:
Nature:
-Density: approx. 1.12g/cm³
-Boiling point: approximately 184-186°C
-Melting point: approx. -33°C
-Refractive index: about 1.52
-Solubility: Soluble in organic solvents such as ethanol, ether and dichloromethane
Use:
- 1-(2,4-difluorophenyl)ethanamine can be used as an intermediate in organic synthesis, for example, it plays a key role in drug synthesis
-It can also be used as a reducing agent and reagent in organic synthesis reactions
Preparation Method:
1-(2,4-difluorophenyl)ethanamine can be synthesized by the following steps:
1. the substitution reaction of aromatic amine (difluoroaniline) and acetaldehyde to generate ethyl aromatic amine.
2. Under alkaline conditions, using an electrophilic reagent such as bromine, the ethyl aromatic amine is further substituted to obtain 1-(2,4-difluorophenyl)ethanamine.
Safety Information:
- 1-(2,4-difluorophenyl)ethanamine need to be stored in a dark, dry place, away from fire and oxidizing agents.
-Wear appropriate protective equipment such as gloves, glasses and protective clothing when using or handling the compound.
-Avoid inhalation, swallowing or contact with skin. If contact with skin or eyes occurs, rinse immediately with plenty of water and seek medical help if necessary.
-Store, treat and dispose of waste in accordance with local laws and regulations.
Last Update:2024-04-09 15:17:58