Name | Adenosine Cyclophosphate |
Synonyms | CAMP Acrasin CYCLIC AMP cyclic amp CYCLIC AMP-3',5' 5'-cyclicmonophosphate 5'-Cyclic Monophosphate Adenosine Cyclophosphate Adenosine 3',5'-phosphate Adenosine 3',5'-cyclic monophosphate 3'-5' cyclic adenosine monophosphate adenosine 3',5'-phosphate monohydrate CAMP, ADENOSINE-3',5'-CYCLIC MONOPHOSPHATE 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide (4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide (4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide |
CAS | 60-92-4 |
EINECS | 200-492-9 |
InChI | InChI=1/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 |
Molecular Formula | C10H12N5O6P |
Molar Mass | 329.21 |
Density | 2.47±0.1 g/cm3(Predicted) |
Melting Point | 260°C (dec.)(lit.) |
Boling Point | 56.12°C |
Specific Rotation(α) | -53.7 º (c=0.7,water) |
Flash Point | 378°C |
Water Solubility | 50 mg/mL |
Solubility | Slightly soluble in water, almost insoluble in ethanol or ether. |
Vapor Presure | 1.18E-20mmHg at 25°C |
Appearance | White powder |
Color | white |
Merck | 14,2708 |
BRN | 52645 |
pKa | 1.00±0.60(Predicted) |
Storage Condition | -20°C |
MDL | MFCD00005845 |
Physical and Chemical Properties | Melting point 260°C specific optical rotation -53.7 ° (c = 0.7,water) water solubility 50 mg/mL properties: This product is white or off-white powder, slightly acidic in taste, slightly soluble in water, almost insoluble in ethanol and ether. This product is a protein kinase activator, which can be used for pharmaceutical intermediates and biochemical reagents. The preparation is clinically used for coronary heart disease, myocardial infarction, and can relieve leukemia. |
Use | For the relief of angina and acute, chronic myocardial infarction and other diseases |
Risk Codes | R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | AU7357600 |
FLUKA BRAND F CODES | 10-21 |
TSCA | Yes |
HS Code | 29349990 |
Toxicity | oms-hmn:oth 100 mmol/L JIDEAE 65,52,75 |
Reference Show more | 1. Ji Xiaolong, Hou Chunyan, Liu Yanqi. Effects of different sterilization and drying methods on the content of cyclic nucleotides in Jujube [J]. Food Science and Technology 2020 v.45;No.340(02):56-62. 2. Wang Kunhua, Li jiamee, Peng Fei, etc. Effect of radio frequency treatment on drying kinetics and quality characteristics of jujube by medium and short wave infrared spectroscopy [J]. Food Science, 2020(7). 3. Yang Yunfei Yu Ruian Xu Kaicheng et al. Simultaneous determination of cAMP and cGMP in rat plasma by LC-MS/MS [J]. Journal of Pharmaceutical Analysis, 2015, 035(006):1022-1026. 4. Liu Dan, Sui Yuehong, Chen Peng, et al. Study on HPLC fingerprint and quantitative determination of 17 introduced jujube varieties in Tarim Basin [J]. Chinese Herbal Medicine, 2015, 46(021):3248-3252. 5. Li Gao Yan Sun Zhao Qian Guo Qing Mei Zhou Feng Qin. Analysis of nutritional components of four kinds of jujube [J]. Shandong Science 2017 30(03):33-39. 6. Dong Li, raiting Xue. Effect of high temperature and high humidity gas impact treatment on quality of mid-short wave infrared dried jujube [J]. Food Research and Development, 2020,41(22):107-112. 7. Bi, J., chen, Q., zhou, Y. et al. Optimization of Short- and Medium-Wave Infrared Drying and Quality Evaluation of Jujube Powder. Food Bioprocess Technol 7, 2375-2387 (2014). https://doi.org/10.1007/s11947-013-1245-y 8. Gao, Lin, et al. "Original Paper Investigation of Processing Technology for Aged Black Jujube." Food Science and Nutrition 3.4 (2019).ttp://dx.doi.org/10.22158/fsns.v3n4p107 9. Shan, Tong, et al. "Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast." Clinical Medicine Research 9.1 (2020): 11.doi: 10.11648/j.cmr.20200901.13 10. [IF=4.465] Bi Jinfeng et al."Optimization of Short- and Medium-Wave Infrared Drying and Quality Evaluation of Jujube Powder."Food Bioprocess Tech. 2014 Aug;7(8):2375-2387 11. [IF=0] Yongpeng Tong et al."A novel EGFR-TKI inhibitor (cAMP-H3BO3complex) combined with thermal therapy is a promising strategy to improve lung cancer treatment outcomes."Oncotarget. 2017 Aug 22; 8(34): 56327-56337 12. [IF=3.645] Fei Li et al."Hydrophilic molecularly imprinted polymers functionalized magnetic carbon nanotubes for selective extraction of cyclic adenosine monophosphate from winter jujube."J Sep Sci. 2021 May;44(10):2131-2142 13. [IF=2.727] Yanlei Zhang et al."Active components and antioxidant activity of thirty-seven varieties of Chinese jujube fruits (Ziziphus jujuba Mill.)."Int J Food Prop. 2021;24(1):1479-1494 |
This product is 6-amino-9-b-d-ribofuranosyl-9h-purin-4, 5 '-cyclic hydrogen phosphate. The content of Cl0H12N506P shall be 97.0% to 103.0% calculated as dry product.
take 0.10g of this product, add 50ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 2.0~4.0.
take 0.lg of this product, add 50ml of water to dissolve, check according to law (General rule 0901 first method and general rule 0902 first method), the solution should be clear and colorless.
take this product, add water to dissolve and dilute it to a solution containing about 0.5mg per 1ml as a test solution; Take 1ml for precision measurement, put it in a 100ml measuring flask, dilute it with water to the scale, as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are accurately measured and injected into the human liquid chromatograph respectively, the chromatogram was recorded to about 4 times the retention time of the main peak (to adenosine triphosphate peak). If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
take this product, dry to constant weight at 105°C, weight loss shall not exceed 10.0% (General rule 0831).
take l.Og of this product, put it in a cobalt crucible, and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
take 0.50g of this product, inspection according to law (General rule 0821 third law), containing heavy metals shall not exceed 20 parts per million.
take this product, check according to law (General rule 1143), the amount of endotoxin per 1 mg cyclic adenosine monophosphate should be less than 3.7EU.
measured by high performance liquid chromatography (General 0512).
silica gel bonded with octylsilane as filler; Mixed solution of potassium dihydrogen phosphate solution and tetrabutylammonium bromide (6.8g of potassium dihydrogen phosphate and 3.2g of tetrabutylammonium bromide, dissolved in water and diluted to 1000ml, shake, adjust pH to 4.3 with phosphoric acid)-acetonitrile (85:15) as mobile phase; Detection wavelength was 258nm. Take about 10 mg of cyclic adenosine monophosphate reference substance, add 5ml of water to dissolve, add 1ml of 1 mol/ L hydrochloric acid solution, heat in water bath for 30 minutes, cool down, and adjust to Neutral with sodium hydroxide solution, dilute with water to make a solution containing about 0.2mg per 1ml, and inject 20u1 into the human liquid chromatograph to adjust the chromatographic system. The resolution of adenosine cyclophosphate peak and adjacent impurity peaks shall meet the requirements. The number of theoretical plates shall not be less than 2000 and the tailing factor shall be less than 1.4 according to the calculation of the peak of cyclic adenosine monophosphate.
take an appropriate amount of this product, weigh it accurately, add water to dissolve and quantitatively dilute it to make it contain about 0 in each lml. 1 mg solution, as the test solution, the precise amount of 20u1 is injected into the liquid chromatograph, and the chromatogram is recorded. In addition, an appropriate amount of cyclic adenosine monophosphate reference substance is taken and determined by the same method, and the peak area is calculated according to the external standard method.
vasodilators.
sealed and kept in a cool place.
This product is a sterile freeze-dried product of cyclic adenosine monophosphate. Cyclic adenosine monophosphate (C10H12N5O6P) shall be 90.0% to 110.0% of the labeled amount calculated as the average loading.
This product is white or off-white loose block or powder.
take this product, according to the identification test under cyclic adenosine monophosphate, showed the same results.
an appropriate amount of the content (approximately equivalent to 20mg of cyclic adenosine monophosphate) under the item of difference in loading amount is accurately weighed, dissolved by adding water and quantitatively diluted to make a content of approximately cyclic adenosine monophosphate O per 1 ml. A solution of 1 mg was used as a test solution. According to the method under the item of cyclic adenosine monophosphate, obtained.
Same as cyclic adenosine monophosphate.
(l)20mg (2)40mg (3)60mg
sealed and stored in a cool place.