Name | 6-bromo-2-chloroquinoxaline |
Synonyms | 6-bromo-2-chloroquinoxaline quinoxaline, 6-bromo-2-chloro- Quinoxaline, 6-bromo-2-chloro- |
CAS | 55687-02-0 |
InChI | InChI=1/C8H4BrClN2/c9-5-1-2-6-7(3-5)11-4-8(10)12-6/h1-4H |
Molecular Formula | C8H4BrClN2 |
Molar Mass | 243.49 |
Density | 1.762±0.06 g/cm3(Predicted) |
Melting Point | 150-152.5 °C |
Boling Point | 312.5±37.0 °C(Predicted) |
Flash Point | 142.8°C |
Vapor Presure | 0.000966mmHg at 25°C |
pKa | -2.46±0.30(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.691 |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
Application | 6-bromo-2-chloroquinoxaline can be used as intermediates in organic synthesis and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical generation process. |
Use | 6-bromo-2-chloroquinoxaline is a quinoline derivative and is useful as a pharmaceutical intermediate. |
preparation | in three vials, add 6-bromo-2-hydroxyquinoxaline, tetra-n-butyl ammonium chloride, phosphorus pentoxide, A reflux condenser was added, toluene was added, and the mixture was thoroughly stirred and dissolved. The temperature was slowly raised to 90 ° C. And the reaction was carried out for 4 hours. The heating was stopped and left to cool to room temperature, and the system was changed to two layers. The supernatant liquid was collected, and the lower viscous substance was washed with toluene, the toluene phase was combined with the supernatant, washed with saturated sodium bicarbonate solution 3 times, the oily phase was collected and dried over anhydrous magnesium sulfate, and filtered, the solvent was removed by rotary evaporation and purified by column chromatography. The eluent was petroleum ether-ethyl acetate (V/V = 5:1), and the eluate was collected to obtain 6-bromo-2-chloroquinoxaline. |