6-Methoxy-3-indolecarboxylic Acid
6-Methoxy-1H-indole-3-carboxylic acid
CAS: 90924-43-9
Molecular Formula: C10H9NO3
6-Methoxy-3-indolecarboxylic Acid - Names and Identifiers
| Name | 6-Methoxy-1H-indole-3-carboxylic acid |
| Synonyms | 6-Methoxy-3-indolecarboxylic Acid 6-METHOXYINDOLE-3-CARBOXYLIC ACID Indole-3-carboxylic acid, 6-methoxy- 6-METHOXY-1H-INDOLE-3-CARBOXYLIC ACID 6-Methoxy-1H-indole-3-carboxylic acid 1H-Indole-3-carboxylicacid, 6-Methoxy- 1H-Indole-3-carboxylic acid, 6-methoxy- 6-METHOXY-2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID |
| CAS | 90924-43-9 |
| InChI | InChI=1/C10H9NO3/c1-14-6-2-3-7-8(10(12)13)5-11-9(7)4-6/h2-5,11H,1H3,(H,12,13) |
6-Methoxy-3-indolecarboxylic Acid - Physico-chemical Properties
| Molecular Formula | C10H9NO3 |
| Molar Mass | 191.18 |
| Density | 1.381g/cm3 |
| Boling Point | 447.575°C at 760 mmHg |
| Flash Point | 224.486°C |
| Vapor Presure | 0mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.677 |
6-Methoxy-3-indolecarboxylic Acid - Reference Information
| Use | substituted indole-3-carboxylic acid compounds are a class of compounds having an indole ring structure and a carboxyl group at the 3-position, substituted indole -3-carboxylic acid can be used for the synthesis of Spiro compounds with special physiological activity, for the treatment of mental illness, stomach disease, migraine and so on. The use of these compounds is very extensive, is an important pesticide, pharmaceutical intermediates. |
| preparation | There are two methods for the synthesis of 6-methoxy-indole-3-carboxylic acid compounds, the first one: 6-methoxy-indole-3-carbaldehyde was prepared from 6-methoxy-indole by Vilsmeier-Hacck reaction, then, the aldehyde group was oxidized by potassium permanganate to obtain 6-methoxy-indole-3-carboxylic acid. Second: hydrolysis of 6-methoxy-indole-3-carbonitrile, the method mainly has three steps, firstly, 6-methoxy-indole was used as raw material to prepare 6-methoxy-indole-3-carbaldehyde by Vilsmeier-Hacck reaction, then, 6-methoxy-indole-3-carbonitrile was synthesized by one-step reaction of 6-methoxy-indole-3-carbaldehyde and hydroxylamine hydrochloride, re-hydrolysis gave 6-methoxy-indole-3-carboxylic acid. The reaction formula for the synthesis of 6-methoxy-3-indolecarboxylic acid is shown below: |
Last Update：2024-04-09 21:32:09
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View History
6-Methoxy-3-indolecarboxylic Acid
Pentasaccharide N-3 Intermediate
Pregn-4-ene-3,11,20-trione, 17-hydroxy-21-[(1-oxoundecyl)oxy]- (9CI)
1-[(Tert-butoxy)carbonyl]-2-methylazetidine-3-carboxylic acid
Racemic Tamsulosin Hydrochloride (50 mg)
1-Naphthalenamine, 2-methyl-5-phenyl-
2-(氨甲基)-1H苯并[d]咪唑-6-羧酸盐酸盐
1H-Pyrazole-4-carboxaldehyde, 1-methyl-3-nitro- (9CI)
Tubotaiwin
LUP-20(29)-EN-28-OIC ACID, 3-[Β-D-GLUCOPYRANOSYL(1→4)[A-L-RHAMNOPYRANOSYL) (1→2)-A -L-ARABINOPYRANOSYL]OXY], (3Β,4A)-)
Pentasaccharide N-3 Intermediate
Pregn-4-ene-3,11,20-trione, 17-hydroxy-21-[(1-oxoundecyl)oxy]- (9CI)
1-[(Tert-butoxy)carbonyl]-2-methylazetidine-3-carboxylic acid
Racemic Tamsulosin Hydrochloride (50 mg)
1-Naphthalenamine, 2-methyl-5-phenyl-
2-(氨甲基)-1H苯并[d]咪唑-6-羧酸盐酸盐
1H-Pyrazole-4-carboxaldehyde, 1-methyl-3-nitro- (9CI)
Tubotaiwin
LUP-20(29)-EN-28-OIC ACID, 3-[Β-D-GLUCOPYRANOSYL(1→4)[A-L-RHAMNOPYRANOSYL) (1→2)-A -L-ARABINOPYRANOSYL]OXY], (3Β,4A)-)