6-Chloro-5-fluoro-2-oxindole - Names and Identifiers
6-Chloro-5-fluoro-2-oxindole - Physico-chemical Properties
Molecular Formula | C8H5ClFNO
|
Molar Mass | 185.58 |
Density | 1.458 |
Melting Point | 196-206 °C |
Boling Point | 327 °C |
Flash Point | 152 °C |
Vapor Presure | 0mmHg at 25°C |
pKa | 12.04±0.20(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.577 |
6-Chloro-5-fluoro-2-oxindole - Introduction
6-Chloro-5-fluoro-1, 3-dihydro-2H-indol-2-one (abbreviated as CFI) is an organic compound. The following is a description of the nature, use, preparation and safety information of CFI:
Nature:
-Appearance: Colorless or pale yellow crystalline solid.
-Melting point: about 80-82°C.
-Boiling point: about 180-182°C.
-Solubility: Almost insoluble in water, soluble in common organic solvents (such as ethanol, dimethylformamide).
Use:
CFI has a wide range of applications, including but not limited to the following:
-Organic synthesis: CFI can be used as an important intermediate for organic synthesis reactions, such as the preparation of indole compounds.
-Drug research: CFI is often used to prepare compound libraries, high-throughput screening, and drug design to find the biological activity of new drugs or compounds.
Preparation Method:
There are many preparation methods for CFI, one of which is commonly used as follows:
Dissolve chloropyran in anhydrous ethanol, add hydrofluoric acid, and then add filtered sodium fluoride. After a period of reaction, filter to remove the precipitate, and add dilute hydrochloric acid to generate crystals.
Safety Information:
- CFI is toxic and should be handled with caution. Avoid contact with skin and eyes during operation, and wear protective gloves, goggles and protective clothing.
-should be away from fire and high heat environment, stored in a dry, well-ventilated place.
-Under no circumstances should it be discharged directly or indirectly into a body of water, soil or sewer.
-If contact or inhalation occurs, immediately flush the affected area with clean water and seek medical help.
Last Update:2024-04-09 15:17:50