Molecular Formula | C9H11N5O3 |
Molar Mass | 237.22 |
Density | 1.3472 (rough estimate) |
Melting Point | >210°C dec. |
Boling Point | 379.74°C (rough estimate) |
Specific Rotation(α) | D24 -50° (c = 0.4 in 0.1N HCl); D24 -26° (c = 0.92 in 0.1N NaOH) |
Flash Point | 295.2°C |
Solubility | Bioptein is very slightly soluble in water. The solubility of biopterin is about 0.01 |
Vapor Presure | 1.4E-13mmHg at 25°C |
Appearance | Crystalline solid |
Color | White to Light Yellow |
Merck | 13,1229 |
BRN | 87860 |
pKa | 13.18±0.20(Predicted) |
Storage Condition | 2-8°C |
Stability | Hygroscopic |
Refractive Index | 1.7610 (estimate) |
MDL | MFCD00036787 |
Use | 6-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). In vitro, 6-Biopterin is cytotoxic to melanocytes. However, in vivo, 6-Biopterin is rapidly and sequentially reduced back to 6-GH4 |
In vitro study | 6-biopterin is extremely cytotoxic to human melanocytes under in vitro conditions. Thioredoxin reductase has the capacity to reduce 6-biopterin to q-BH2 where further reduction to 6-BH4 follows via dihydropteridine reductase or reduced glutathione. (6R)5,6,7,8 tetrahydrobiopterin undergoes redox-cycling by its oxidation to quinonoid dihydrobiopterin and to 6-biopterin through consecutive two electron oxidation reactions. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | UO3506000 |
FLUKA BRAND F CODES | 10-23 |
HS Code | 29339900 |
Toxicity | sln-par-dmg 10 mg/L MUREAV 128,147,84 |