Name | Glabridin |
Synonyms | Glabridin professional manufacturer Glabridin 59870-68-7 4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol |
CAS | 59870-68-7 |
EINECS | 611-908-7 |
InChI | InChI=1/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1 |
InChIKey | PMPYOYXFIHXBJI-ZDUSSCGKSA-N |
Molecular Formula | C20H20O4 |
Molar Mass | 324.37 |
Density | 1.257±0.06 g/cm3(Predicted) |
Melting Point | 154~155℃ |
Boling Point | 518.6±50.0 °C(Predicted) |
Specific Rotation(α) | (c, 2.07 in CHCl3)+8.2 |
Flash Point | 267℃ |
Solubility | Insoluble in water, easily soluble in organic solvents, such as propylene glycol, etc. |
Vapor Presure | 2.26E-11mmHg at 25°C |
Appearance | Pale yellow powder |
Color | white to light brown |
BRN | 7141956 |
pKa | 9.66±0.40(Predicted) |
Storage Condition | room temp |
Stability | Hygroscopic |
Refractive Index | 1.622 |
MDL | MFCD03427694 |
Physical and Chemical Properties | Dried rhizomes derived from Glycyrrhiza glabra |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
HS Code | 29329990 |
Reference Show more | 1. Zhu Zibo, Fan Jinling, Cheng Yuanbin, et al. Study on hypoglycemic activity of acid extract residue from Glycyrrhiza glabra [J]. Food Science and Technology 2019 v.44;No.332(06):238-246. 2. Huang Shangjun, Li Chunjun, Huang Jianfeng, Mo dunchang, Luo Penhui, Wang hanlei. Effect of glabridin on proliferation, invasion and apoptosis of cervical cancer Hela cells and its mechanism [J]. Modern medical oncology 2020 v.28;No.301(19):16-20. 3. Yang Xiaoping, Zhou Duo, a soldier, Ding Yanhui, et al. Effects of glabridin on proliferation and apoptosis of colorectal cancer RKO cells [J]. Journal of Anhui Medical University 2017(1). 4. Huang shangxiao, Li Chunjun, Huang Jianfeng, Mo dunchang, Luo Penhui, Wang hanlei. Effects of glabridin on proliferation, invasion and apoptosis of cervical cancer Hela cells and its mechanism [J]. Modern cancer medicine, 2020,28(19):3289-3293. 5. [IF = 2.629] Li Tingting et al."Quality Assessment of Licorice Based on Quantitative Analysis of Multicomponents by Single Marker Combined with HPLC finger print. Evid-Based Compl Alt. 2021;2021:8834826 6. [IF = 1.885] Xia Wenxin et al."Study on the Spectrum-Effect Relationship of the Traditional Effect of Saponins in Glycyrrhiza uralensis Fisch."Int J Anal Chem. 2021;2021:6617033 7. [IF=4.36] Qingquan Guo et al."Glabrol impurity exacerbates glabridin toxicity in zebrafish embryos by increasing myofibril disorganization."J Ethnopharmacol. 2022 Apr;287:114963 |
Plant Source: | licorice |
Introduction | glabridin is a natural whitening agent isolated from licorice flavonoids, licorice flavonoids is extracted from the rhizomes of specific varieties of licorice plants (such as Glycyrrhiza uralensis, Glycyrrhiza inflata, Glycyrrhiza glabra, etc.), all natural, pollution-free, without any side effects on the human body. At room temperature for red-brown powder, insoluble in water, soluble in organic solvents, such as ethanol, propylene glycol, 1, 3-butanediol and so on. Glycyrrhiza glabra is a perennial herb that grows in southern Europe, Asia, and the Mediterranean, and is widely cultivated in Russia, Spain, Iran, and India. Glabridin can be phlegm, emollient, anti-inflammatory, anti-viral pathogens, anti-liver toxins and antibacterial. Because of its efficacy, licorice has been extensively studied in both medicine and food. Licorice can be used in cosmetics, it has whitening, anti-inflammatory, antibacterial and antioxidant effects, is a very valuable cosmetic raw materials. glabridin, because of its efficient ability to inhibit reactive oxygen species and melanin, is known as "whitening gold", one is the acclaim of whitening efficacy, second, the price of a single gram of glabridin is equivalent to that of gold, and only a few brands are willing to use it as a whitening ingredient. |
efficacy and function | glabridin has strong antibacterial, anti-inflammation caused by UV, pigmentation and skin roughness, can remove superoxide ion, inhibit the hemolysis caused by hydrogen peroxide, it can inhibit the activity of tyrosinase, and can inhibit the activity of DOPA pigment interconversion and DHICA oxidase, is a rapid, efficient, green whitening freckle cosmetic additives, with SOD (superoxide dismutase) similar to the ability of scavenging oxygen free radicals, but also with vitamin E similar to the ability of anti-oxygen free radicals. In addition, glabridin also has a strong oxidation, anti-atherosclerosis, and has a certain role in reducing blood fat and blood pressure. |
pharmacological effects | glabridin is one of the main flavonoids in Glycyrrhiza glabra. It shows strong anti-free radical oxidation in cytochrome P450/NADPH oxidation system, can significantly inhibit the metabolism of free radicals, from oxidation sensitive of biological macromolecules (low density lipoprotein LDL,DNA) and cell wall, such as free radical oxidative damage. it can prevent and treat some pathological changes related to free radical oxidation, such as atherosclerosis, cell senescence, etc. In addition, glabridin also has certain hypolipidemic and hypotensive effects. |
Use | glabridin is a compound extracted from licorice (root), which is cytotoxic, antibacterial, estrogenic and antiproliferative properties. for content determination/identification/pharmacological experiments and other pharmacological effects: inhibition of active oxygen production, inhibition of tyrosinase, anti-inflammatory, antioxidant effects. |
licorice flavonoids | so far, there is only one kind of licorice antioxidant, which is a mixture of flavonoids and flavonoids. China's health standards for the use of food additives (GB2760): licorice antioxidants can be used for oil, fried foods, pickled fish, meat products, biscuits, instant noodles, oil food. The maximum amount of 0.2g/kg. In the field of domestic cosmetics, domestic products also use licorice flavonoids production freckle products. China's cosmetics (skin care products) market in 2011 sales exceeded 200 billion yuan, the market size among the world's third. It is reported that the sales of cosmetics (skin care products) in China maintain a sales growth rate of 15% per year. Licorice flavonoids whitening freckle effect is remarkable, I believe that in the future cosmetics market should have a better development prospect. |