Molecular Formula | C16H17NO3 |
Molar Mass | 271.31 |
Density | 1.317±0.06 g/cm3(Predicted) |
Melting Point | 208-210 °C |
Boling Point | 522.4±50.0 °C(Predicted) |
Flash Point | 209.6°C |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 1.56E-11mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
pKa | 9.72±0.40(Predicted) |
Storage Condition | Refrigerator |
Refractive Index | 1.666 |
Overview | noraconitine, also known as demethylhengzhou aconitine, is an antiarrhythmic drug. This product is the active ingredient of aconite, can enhance myocardial contractility, speed up the heart rate; Dilate the heart, brain and surrounding blood vessels; Improve the role of chronic arrhythmia. It is clinically used for the treatment of chronic arrhythmia and sick sinus syndrome. |
biological activity | Demethyl-Coclaurine (Higenamine, norcorourine) is a key component of Aconitum root, it is an agonist of beta-2 adreneric receptor (β2-AR). Demethyl-Coclaurine can stimulate the phosphorylation of AKT, and the activation of PI3K is required for the anti apoptotic effect of myocardial cells. |
Target | Value |
category | toxic substances |
toxicity grade | poisoning |
Acute toxicity | oral-mouse LD50: 3350 mg/kg; Intraperitoneal-mouse LD50: 300 mg/kg |
flammability hazard characteristics | flammable; Thermal decomposition of toxic nitrogen oxide gases |
storage and transportation characteristics | warehouse low temperature, ventilation, dry |
extinguishing agent | water, carbon dioxide, dry powder, sand |