Update Date: | 2022/11/12 12:49:22 |
New cyanide antidote | hydroxycobalamin hydrochloride is a safe, non-toxic, rapid-acting New cyanide antidote, in view of the particularity of cyanide poisoning treatment, the US FDA approved hydroxycobalamin for the treatment of known or suspected cyanide poisoning through the priority review channel on December 15, 2006, hydroxycobalamin hydrochloride became the first emergency medicine approved for cyanide poisoning in the United States. Hydroxycobalamin hydrochloride can quickly complex with cyanide ion in vivo, and the cyanide ion replaces the hydroxyl group coordinated by the cobalt ion in the hydroxycobalamin molecule, A stable, non-toxic product, cyanocobalamin (I. E., VB12), was formed and cleared by urine. Compared with other cyanide antidotes currently in clinical use, the most prominent advantages of hydroxycobalamin hydrochloride are:(1) it can be used for the treatment of suspected cyanide poisoning, so it is particularly suitable for out-of-hospital emergency treatment at the scene of the accident. (2) the detoxification process does not require the participation of hemoglobin, which does not affect the oxygen carrying capacity of the blood in the body, and can be used for the emergency treatment of cyanide poisoning under the condition of hypoxia. Other studies have found that hydroxycobalamin hydrochloride is superior to adenosine coenzyme B12 in improving the symptoms and signs of diabetic neuropathy. Hydroxycobalamin hydrochloride is not only effective in the treatment of cyanide poisoning, but also has a wide range of indications and a large market development space. |
properties | dark red crystalline powder, odorless, tasteless, with strong hygroscopicity, soluble in water, slightly soluble in ethanol, benzene, insoluble in ether, acetone, carbon tetrachloride. |
pharmacokinetics | This product was rapidly absorbed after injection, peaked in 60 minutes, and transported cobalt amine II with blood. And plasma β-globin binding, mainly 90% stored in liver cells and metabolism. Half-Life (t1/2) about 6 days. |
indications | for the treatment of pernicious anemia, megaloblastic anemia, neuralgia, liver parenchyma damage and contact dermatitis. The drug is also an antidote for cyanide. |
apply | vitamin fortifier. |