Name | Metalaxyl |
Synonyms | Subdue subdue2e Metalaxyl ridomil2e Acylon(Ciba-Geigy) methyl N-(methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate n-(methoxyacetyl)-n-(2,6-xylyl)-,methylester,dl-alanin methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)-DL-alaninate n-(2,6-dimethylphenyl)-n-(methoxyacetyl)-dl-alaninmethylester N-(2,6-Dimethylphenyl)-N-(methoxy acetyl)-alanine methyl ester n-(2,6-dimethylphenyl)-n-(methoxyacetyl)-dl-alaninemethylester |
CAS | 57837-19-1 |
EINECS | 260-979-7 |
InChI | InChI=1/C15H21NO4/c1-10-7-6-8-11(2)14(10)16(13(17)9-19-4)12(3)15(18)20-5/h6-8,12H,9H2,1-5H3 |
Molecular Formula | C15H21NO4 |
Molar Mass | 279.33 |
Density | 1.1083 (rough estimate) |
Melting Point | 72-73°C |
Boling Point | 422.1°C (rough estimate) |
Flash Point | 100°C |
Water Solubility | 0.84 g/100 mL |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Vapor Presure | 7.5 x 10-4 Pa (25 °C) |
Appearance | neat |
Color | Off-White to Pale Beige |
BRN | 2947777 |
pKa | 1.41±0.50(Predicted) |
Storage Condition | Sealed in dry,2-8°C |
Refractive Index | 1.5130 (estimate) |
Physical and Chemical Properties | Melting Point 72-73°C water-soluble 0.84g/100 mL |
Use | It is an systemic fungicide, used as a fungicide for tobacco, rubber tree, grape, hops, fruits, vegetables and other |
Risk Codes | R22 - Harmful if swallowed R43 - May cause sensitization by skin contact R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S13 - Keep away from food, drink and animal foodstuffs. S24 - Avoid contact with skin. S37 - Wear suitable gloves. S46 - If swallowed, seek medical advice immediately and show this container or label. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. |
UN IDs | UN 1648 3/PG 2 |
WGK Germany | 2 |
RTECS | AY6910000 |
HS Code | 29242990 |
Toxicity | LD50 in rats (mg/kg): 669 orally (Urech) |
white crystals. The melting point is 71~72 ℃, the vapor pressure (20 ℃)2.933 × 10 -4 Pa, the relative density (20 ℃)1.21. Soluble in a variety of organic solvents, methanol solubility of 65%; Water solubility (20 degrees C) of 0.71%. It is more stable in acidic and neutral medium. Non-flammable, non-explosive, non-corrosive.
first, three compounds of methyl a-chloropropionate, 2, 6-dimethylaniline and methoxyacetic acid were prepared. Finally, metalaxyl was prepared. (1) chloropropionic acid and methanol are directly esterified under the condition of concentrated sulfuric acid as catalyst, anhydrous calcium chloride is added as dehydrating agent, and the reaction is stirred at 50~60 ° C. To obtain methyl a-chloropropionate. Methyl a-chloropropionate can also be prepared by reacting phosgene with a-chloropropionic acid to form a-chloropropionyl chloride and then reacting with methanol. (2) nitration of M-xylene with mixed acid, separation of 2,4-= methylnitrobenzene to give 2. 6-= methylnitrobenzene, and reduction with hydrogen to give 2,6-methylaniline. (3) ethylene glycol and methyl ether are oxidized with nitric acid, and the reaction is carried out under the action of a vanadium salt and a copper salt as a catalyst to obtain methoxyacetic acid. The 2,6-= methyl aniline obtained above was reacted with methyl a monochloropropionate, anhydrous sodium carbonate was used as acid binding agent, and a small amount of iodine catalyst was added to obtain N-(2 'methyl propionate). -2,6-= methylaniline. Methoxyacetic acid and appropriate amount of toluene were heated, phosphorus trichloride was added dropwise, and the reaction was continued. The lower phosphorous acid was removed to obtain methoxyacetyl chloride toluene solution, and then N-(2 '-methyl propionate)-2 was added dropwise. 6-= The Reflux reaction of methylaniline was continued, and metalaxyl was obtained by treatment.
A new type of high efficiency disinfectant. Can be absorbed into the plant, the water solubility is much higher than the general fungicide. It has selective effects on the Frost mold and Phytophthora in the class Oomycetes, such as potato late blight, grape downy mildew, hop downy mildew, sugar beet blight, rape white Rust, tobacco black shank and so on have good control effect. Also can be used for cotton sudden fall disease, Millet White Disease, good control effect.
The oral LD50 of male rats and mice was 66 9mg/kg, and the percutaneous LD50 of rats was> 3100mg/kg. Rats 2 years feeding test no effect of the dose of/50mg/kg (equivalent to 2.5mg/kg per day), under the experimental conditions, no animal has carcinogenic, teratogenic, mutagenic effects. The third generation reproductive test showed no abnormality. Carp, rainbow trout LC50 lOOmg/L; Bee LCso 20ug/only; Quail LC50 798~1067mg/kg.