Name | Cholesterol |
Synonyms | Cholesterol Cholesterol, NF 5-Cholesten-3B-ol 5-cholesten-3β-ol 5-Cholesten-3beta-ol Cholest-5-en-3beta-ol (3β)-cholest-5-en-3-ol 5,6-Cholesten-3beta-ol 3β-hydroxycholest-5-ene cholesterol from lanolin (3beta)-cholest-5-en-3-ol 3beta-hydroxycholest-5-ene 3beta-hydroxy-5-cholestene cholesterol from hog liver (3.beta.)-Cholest-5-en-3-ol |
CAS | 57-88-5 |
EINECS | 200-353-2 |
InChI | InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 |
InChIKey | HVYWMOMLDIMFJA-DPAQBDIFSA-N |
Molecular Formula | C27H46O |
Molar Mass | 386.66 |
Density | 1.06 |
Melting Point | 148-150°C |
Boling Point | 360 °C |
Specific Rotation(α) | -36 º (c=2, dioxane) |
Flash Point | 250 °C |
Water Solubility | negligible |
Solubility | Insoluble in water, easily soluble in ether, chloroform and other solvents. |
Vapor Presure | 2.95E-11mmHg at 25°C |
Appearance | White powder |
Specific Gravity | 1.067 |
Color | white |
Merck | 14,2201 |
BRN | 1915888 |
pKa | 15.03±0.70(Predicted) |
Storage Condition | -20°C |
Sensitive | Sensitive to heat and air |
Refractive Index | 1.5250 (estimate) |
MDL | MFCD00003646 |
Physical and Chemical Properties | Density 1.06 melting point 147-150°C boiling point 360°C flash point 250°C specific optical rotation -36 ° (c = 2, dioxane) water-soluble neglignible |
Use | Is an important raw material for the manufacture of hormones, and can be used as emulsifiers |
Risk Codes | R10 - Flammable R48/20/22 - R40 - Limited evidence of a carcinogenic effect R38 - Irritating to the skin R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R67 - Vapors may cause drowsiness and dizziness R36/38 - Irritating to eyes and skin. R20 - Harmful by inhalation R63 - Possible risk of harm to the unborn child |
Safety Description | S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
UN IDs | UN 1170 3/PG 3 |
WGK Germany | 1 |
RTECS | FZ8400000 |
TSCA | Yes |
HS Code | 2906 13 10 |
Hazard Class | IRRITANT |
Toxicity | Present in allparts of the animal body; concentrated in spinal cord, brain, skinsecretions, and gallstones. An unsaturated, unsaponifiable alcohol(m.p. 149℃). It is synthesized in the body from ethanoate units;its metabolism is regulated by a specific set of enzymes. It is theparent compound of many other steroids and its presence in highconcentrations in the blood is suspected as being a contributoryfactor in cardiovascular disease. |
fresh animal brains and ridges were minced and dried at 40-50 ℃ to prepare dry brain powder. Dry brain powder plus 1.2 times the amount of acetone immersion, extraction 4. 5H, repeated extraction 5 times, combined extract. Acetone was recovered from the extract by distillation to obtain a yellow solid. Then, 10 times the amount of ethanol was added, and th was refluxed by heating, filtered, and the filtrate was cooled at 0 to 5 ° C., allowed to stand, precipitated crystals, and filtered to obtain crude cholesterol crystals. Add 5 times the amount of ethanol in the crude product, then add 5% ~ 6% sulfuric acid, heat reflux for 8H, remove lipid impurities, cool the hydrolysate at 0~5 ℃, precipitate crystals, filter, wash to neutrality with ethanol. The crystals were added 10 times the amount of 95% ethanol, 3% activated carbon, heated reflux decolorization th, heat preservation filtration, filtrate 0~5 deg C cooling crystallization, filtration, vacuum drying, cholesterol can be obtained.
This strain is derived from the extraction and purification of animal organs. This product is the bile -5 ENE -3 Lu-alcohol. Calculated as dry product, containing cholesterol (C27 H46 0) not less than 95.0%.
The melting point of this product (General 0612) is 147~150°C.
take this product, precision weighing, plus dioxane dissolution and quantitative dilution of 20mg per lm l solution, according to the law (General 0621), the specific rotation should be from one 34 ° to one 38 °.
artificial bezoar and hormone drugs can also be used as emulsifiers. Chemical raw materials, surfactants, cosmetics raw materials.
sealed storage.
take this product l.O g, put it in a plug Erlenmeyer flask, Add 10ml of ether to dissolve, and then add O .lm o l/L sodium hydroxide solution 10ml, shake for about 1 min, slowly heat to remove ether, boil for 5 min, let cool, add water 10ml, add 2 drops of phenolphthalein indicator solution under magnetic stirring, with sulfuric acid titration solution (0 .05 ol/L m) titration to pink disappeared, while doing blank test. The difference between the milliliters of sulfuric acid titrant consumed in the blank test and the milliliters of sulfuric acid titrant consumed in the sample shall not exceed 0. 3ml.
take 0. 5 g of this product, add 50ml ethanol, warm to dissolve, stand for 2 hours, do not produce precipitation or turbidity.
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.3% (General rule 0831).
take l g of this product and check it according to law (General rule 0841). The remaining residue shall not exceed.
The residue left under the ignition residue item shall be inspected according to law (General rule 0821, Law 2), and the heavy metal content shall not exceed 10 parts per million.
take this product l.O g, add calcium hydroxide l.O g, mix, add a small amount of water to stir the loop evenly, after drying, burn with small fire to charring, then burn at 500~600°C to make it ash completely, and let it cool, add hydrochloric acid 5M l and water 23ml to dissolve, check according to law (General Principles 0822 The first law), should comply with the provisions (0.0002%).
measured by high performance liquid chromatography (General 0512).
pharmaceutical excipients, emulsifiers and soft matrix.
light shielding, closed storage.