Name | Stearic acid |
Synonyms | C18 FEMA 3035 Stearic acid hystrene5016 hystrene7018 Octadecan acid CETYLACETIC ACID n-Octadecan acid Octadecanoic acid CARBOXYLIC ACID C18 ACIDUM STEARICUM 50 |
CAS | 57-11-4 |
EINECS | 266-928-5 |
InChI | InChI=1/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20) |
InChIKey | QIQXTHQIDYTFRH-UHFFFAOYSA-N |
Molecular Formula | C18H36O2 |
Molar Mass | 284.48 |
Density | 0.845 g/cm3 |
Melting Point | 67-72 °C (lit.) |
Boling Point | 361 °C (lit.) |
Flash Point | >230°F |
JECFA Number | 116 |
Water Solubility | 0.1-1 g/100 mL at 23 ºC |
Solubility | Insoluble in water, slightly soluble in ethanol, soluble in acetone, benzene, soluble in ether, chloroform, carbon tetrachloride, etc. |
Vapor Presure | 1 mm Hg ( 173.7 °C) |
Appearance | Solid |
Specific Gravity | 0.84 (80℃) |
Color | White |
Exposure Limit | ACGIH: TWA 10 mg/m3; TWA 3 mg/m3 |
Merck | 14,8804 |
BRN | 608585 |
pKa | pKa 5.75±0.00(H2Ot = 35) (Uncertain) |
Storage Condition | Store below +30°C. |
Refractive Index | 1.4299 |
MDL | MFCD00002752 |
Physical and Chemical Properties | Appearance and properties: the pure product is a white soft piece with luster. melting point (℃): 70-71 boiling point (℃): 383 relative density (water = 1): 0.87 relative vapor density (Air = 1): 9.8 saturated vapor pressure (kPa): 0.13(173.7 ℃) flash point (℃): 196 ignition temperature (℃): 395 solubility: insoluble in water, slightly soluble in ethanol, soluble in acetone, benzene, soluble in ether, chloroform, carbon tetrachloride, etc. |
Use | It is widely used as cold-resistant plasticizer, stabilizer, surfactant, release agent, rubber vulcanization accelerator, etc. |
Risk Codes | R38 - Irritating to the skin R36/37/38 - Irritating to eyes, respiratory system and skin. R11 - Highly Flammable |
Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. |
UN IDs | N/A |
WGK Germany | 3 |
RTECS | WI2800000 |
TSCA | Yes |
HS Code | 38231100 |
Toxicity | LD50 i.v. in mice, rats: 23±0.7, 21.5±1.8 mg/kg, L. Or, A. Wretlind, Acta Pharmacol. Toxicol. 18, 141 (1961) |
Reference Show more | 1. Zheng mangrong, LV Xiaoling, Wang Jianxin et al. Comparison of main components and antioxidant capacity of three kinds of sea buckthorn oil [J]. Food Research and Development 2018(8):24-29. 2. Li Lili, Li Yue, Lu Heng, Wang Xiao. Metabolomics analysis of Flos lonicerae at different flowering stages based on liquid chromatography-mass spectrometry [J]. Chinese Journal of analysis and testing, 2020,39(12):1501-1507. 3. Zhan, Y-H, Wei, Y-C, Zhang, H-F, Luo, M-C, Zheng, T-T, Liao, S. Et al. Analysis of the thermogenesis mechanism of natural rubber under high speed strain. Polym Adv Technol. 2020; 31: 1994- 2006. https://doi.org/10.1002/pat.4923 4. [IF = 3.125] Pengfei Liu et al."Effect of five saturated fatty acids on the properties of sweet-potato-starch-based films."J Appl Polym Sci. 2015 Feb;132(5): 5. [IF=9.147] Ling Huang et al."Dietary fatty acid-mediated protein encapsulation simultaneously improving the water-solubility, storage stability, and oral absorption of astaxanthin."Food Hydrocolloid. 2022 Feb;123:107152 6. [IF=7.514] Ping Sun et al."Characterization of functional chocolate formulated using oleogels derived from β-sitosterol with γ-oryzanol/lecithin/stearic acid."Food Chem. 2021 Oct;360:130017 7. [IF=7.514] Zhaojing Jiang et al."Structuring of sunflower oil by stearic acid derivatives: Experimental and molecular modelling studies."Food Chem. 2020 Sep;324:126801 8. [IF=6.953] Dantong Zheng et al."Effect of a novel shell material-Starch-protein-fatty acid ternary nanoparticles on loading levels and in vitro release of curcumin."Int J Biol Macromol. 2021 Dec;192:471 9. [IF=6.707] Wenyan Zhao et al."Environmentally-friendly superhydrophobic surface based on Al2O3@KH560@SiO2 electrokinetic nanoparticle for long-term anti-corrosion in sea water."Appl Surf Sci. 2019 Aug;484:307 10. [IF=6.165] Adel Noubigh et al."Stearic acid solubility in mixed solvents of (water ethanol) and (ethanol ethyl acetate): Experimental data and comparison among different thermodynamic models."J Mol Liq. 2019 Dec;296:112101 11. [IF=5.03] Tingting Zheng et al."Study on the ozone aging mechanism of Natural Rubber."Polym Degrad Stabil. 2021 Apr;186:109514 12. [IF=4.952] Feilong Wei et al."Oleogel-structured emulsion for enhanced oxidative stability of perilla oil: Influence of crystal morphology and cooling temperature."Lwt Food Sci Technol. 2021 Mar;139:110560 13. [IF=4.379] Zhan Yue-Hua et al."Effect of protein on the thermogenesis performance of natural rubber matrix."Sci Rep-Uk. 2020 Oct;10(1):1-9 14. [IF=3.665] Yue-Hua Zhan et al."Analysis of the thermogenesis mechanism of natural rubber under high speed strain."Polym Advan Technol. 2020 Sep;31(9):1994-2006 15. [IF=3.638] Ruting Zheng et al.Gelation and Foaming Properties of Fatty Acid Mixtures in Sunflower Oil.Journal Of The Science Of Food And Agriculture.2021 Nov 29 16. [IF=7.514] Donghui Li et al."Fabricating hydrophilic fatty acid-protein particles to encapsulate fucoxanthin: Fatty acid screening, structural characterization, and thermal stability analysis."Food Chem. 2022 Jul;382:132311 17. [IF=7.147] Ziao Zheng et al."Design and optimization of an air-based phase change cold storage unit through cascaded construction for emergency cooling in IDC."Energy. 2022 Feb;241:122897 18. [IF=7.514] Qiongling Chen et al."Effect of fatty acid saturation degree on the rheological properties of pea protein and its high-moisture extruded product quality."FOOD CHEMISTRY. 2022 Oct;390:133139 |
The Pure product is a white leaf-like solid with gloss. Slowly volatilize at 90-100 °c. Almost insoluble in water (20 deg C, 100ml water dissolved only 0. 00029g), soluble in ethanol, acetone, soluble in ether, chloroform, benzene, carbon tetrachloride, carbon disulfide, acetic acid and toluene and so on. In case of high heat, open flame or contact with oxidant, there is a risk of combustion.
The production methods of industrial stearic acid mainly include fractionation method and pressing method. Add decomposition agent in hardened oil, and then hydrolyzed to crude fatty acid, and then washed with water, distillation, decolorization to get the finished product. At the same time, by-product glycerol.
The main components of the solid fatty acids obtained from animal and vegetable oils of this strain are stearic acid (c18h36o2) and palmitic acid (clsh3202). The content of stearic acid (C18H3602) shall not be less than 40.0%, and the total content of stearic acid (C1SH3602) and palmitic acid (C16H3602) shall not be less than 90.0%.
The freezing point of this product (General rule 0613) is not less than 54°C.
The iodine value of this product (General 0713) is not greater than 4.
The acid value of this product (General 0713) is 203~210.
stearic acid is a kind of fatty acid widely existed in nature, almost all oils have different content of stearic acid. In addition to oil-based drilling fluid emulsifier, also used as natural rubber, synthetic rubber (except butyl rubber) and latex vulcanization active agent, also used as plastic plasticizer and stabilizer of raw materials. It is used in the preparation of ointments, suppositories, etc., and also used in the manufacture of cosmetics, candles, waterproofing agents, brighteners, etc. The product is used in the food industry as a lubricant, antifoaming agent and food additives such as Glyceryl stearate, sorbitan stearate, Sucrose ester and other raw materials.
In the chromatogram recorded under the content determination item, the retention time of the two main peaks of the test solution should be consistent with the retention time of the two main peaks of the control solution.
mice and rats were intravenously injected with LD50:(23±0.7) mg/kg, (21.5±1.8) mg/kg. The mice were stored in a cool, ventilated room. Keep away from fire and heat source. Keep the container sealed. Should be stored separately from the oxidant.
take an appropriate amount of this product and heat and melt it on a water bath at 75°C. If the color is colored, it shall not be deeper in comparison with the yellow-green No. 1 Standard Colorimetric solution (General rule 0901).
Take 5.0g of this product, heat and melt, add equal volume of new boiling hot water, shake for 2 minutes, let cool, filter, add 1 drop of methyl orange indicator solution to the filtrate, and do not show red and color.
take 1. 0g of this product, add anhydrous sodium carbonate 0. 5 g and water 30ml, boil to dissolve, the solution should be clear.
take 4 .0g of this product and check it according to law (General rule 0841). The residue shall not exceed 0 .1%.
take 0.10g of this product, put it in a high pressure digestion tank, add an appropriate amount of nitric acid, heat it at 130°C until complete digestion, cool it, transfer it to a 10ml measuring flask, and dilute it to the scale with 1% nitric acid, as a test solution. Prepare blank solution D by the same method. Separately take standard solution of single nickel element and dilute it with 1% nitric acid to prepare 0, 5, 10 and 15mg/ml reference solution D. Take test solution and reference solution, according to Atomic Absorption Spectrophotometry (General Principles 0406, first method), in 232. The wavelength of Onm is measured and calculated, and obtained. The nickel content should not exceed 0.0001%.
The residue left under the item of ignition residue shall be inspected by law (general law 0821, Law II) and shall not contain more than 5 parts per million of heavy metals.
measured by gas chromatography (General rule 0M1).
pharmaceutical excipients, lubricants and ointment base.
sealed storage.