529508-58-5 - Names and Identifiers
529508-58-5 - Physico-chemical Properties
Molecular Formula | C14H10FN3O2
|
Molar Mass | 271.25 |
Density | 1.38±0.1 g/cm3(Predicted) |
Boling Point | 447.7±30.0 °C(Predicted) |
Flash Point | 224.559°C |
Vapor Presure | 0mmHg at 25°C |
pKa | -0.82±0.30(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.654 |
529508-58-5 - Introduction
1-(3-fluorobenzyl)-5-nitro-1H-indazole is an organic compound with the chemical formula C14H9FN3O2. The following is an introduction to some of its properties, uses, methods and safety information:
Nature:
-Appearance: Colorless or light yellow crystalline solid;
-Melting point: about 180-182 degrees Celsius;
-Solubility: Soluble in organic solvents such as chloroform, dichloromethane and ethanol.
Use:
-chemical reagents: intermediates used in drug synthesis and organic synthesis reactions;
-Medical field: Some studies have shown that it may have an inhibitory effect on some cancer cells, but further research is needed to verify;
-scientific purposes: can be used as a starting material for the study of other compounds or as a reference standard.
Preparation Method:
There are many different ways to prepare 1-(3-fluorobenzyl)-5-nitro-1H-indazole. The following is one of the common methods:
-First, benzaldehyde and 3-fluorostyrene are reacted with benzyl under base catalysis to obtain 1-(3-phenylacetyl) benzyl.
-Then, 1-(3-phenylacetyl) benzyl is subjected to nucleophilic substitution reaction with nitric acid catalyzed by sulfuric acid to obtain 1-[(3-phenyl) methyl]-5-nitro-1H-indazole.
-Finally, purification and crystallization by sodium hydroxide or other methods to obtain pure 1-(3-fluorobenzyl)-5-nitro-1H-indazole.
Safety Information:
-The compound is required to follow relevant safety procedures in laboratory environments and industrial operations.
-It may be irritating to the eyes, skin and respiratory tract, and personal protective equipment such as chemical protective gloves, goggles and protective face masks should be used.
-It should be stored in a dry, cool and well-ventilated place, away from fire.
-Avoid contact with oxidizing agents, reducing agents and combustibles during handling and storage.
-If there is a leak or splash on the skin or eyes, rinse immediately and consult a doctor.
Please note that the above information is for reference only. When using and handling this compound, please follow the relevant regulations and safety measures, and consult a professional.
Last Update:2024-04-09 21:01:54