Molecular Formula | C7H7IO |
Molar Mass | 234.03 |
Density | 1.799g/mLat 25°C(lit.) |
Melting Point | 588.5 °C |
Boling Point | 125-126°C19mm Hg(lit.) |
Flash Point | >110°C |
Water Solubility | insoluble |
Solubility | alcohol: miscible(lit.) |
Appearance | Liquid |
Specific Gravity | 1.799 |
Color | Clear yellow |
Merck | 14,5028 |
BRN | 1860243 |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Sensitive | Light Sensitive |
Refractive Index | n20/D 1.622(lit.) |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 8 |
TSCA | Yes |
HS Code | 29093090 |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
properties | 2-iodanisole is a light yellow liquid with a melting point of 8-10°C and a boiling point of 125-126°C (96.8kPa), soluble in organic solvents such as alcohol and ether, insoluble in water, and easy to decompose and precipitate iodine when light is seen. |
application | 2-iodoanisole is an important general chemical reagent, a key synthetic intermediate in pharmacy, liquid crystal, scientific research and other aspects, and has a wide range of applications in the field of organic synthesis. |
preparation | (1) prepare 2 moles of 20% NaI aqueous solution a and 2.1 moles of 8 ~ 10% sodium hypochlorite aqueous solution B for standby;(2) add 900g anisole to a 2L four-mouth round bottom flask equipped with stirring, temperature display and two constant pressure drop funnels, and heat to 60~70 ℃ under stirring. Then, under stirring, according to the molar ratio of 1:1.05, add sodium iodide solution and sodium hypochlorite solution dropwise at the same time;(3) After the dropwise addition, raise the temperature to 75~80 ℃, stir for 1 hour to obtain a light yellow reaction solution; cool to room temperature and stand The phase is divided; the organic phase is washed with water, dried and filtered to obtain an anisole solution of 2-iodoanisole, which is rectified, cooled, and solidified to obtain white lumpy crystals, that is, 2-iodoanisole, its content is ≥ 98.5%, and the yield is 93.4%. |