Fmoc-R-3-Amino-3-(4-hydroxy-phenyl)-propionic acid is an organic compound commonly used in the synthesis of aromatic amino acids and in solid-phase peptide synthesis. Its chemical properties are as follows:
1. Appearance: white solid
2. molecular formula: C26H23NO4
3. molecular weight: 413.46
4. Melting point: 106-110°C
5. storage conditions: in a cool, dry place sealed preservation
Fmoc-R-3-Amino-3-(4-hydroxy-phenyl)-propionic acid is mainly used for the modification or modification of synthetic natural amino acids, especially for peptide synthesis in solid phase synthesis. It can be synthesized by the following steps:
1. An Fmoc-amino acid is obtained by introducing an Fmoc protecting group onto the α-amino group of an amino acid.
2. Under alkaline conditions, 3-(4-hydroxyphenyl) propionic acid is added to the carboxyl group of the amino acid.
3. by a synthetic method, such as the amidation reaction, the Fmoc protecting group is removed to obtain the final Fmoc-R-3-amino -3-(4-hydroxyphenyl) propionic acid.
Regarding safety information, Fmoc-R-3-Amino-3-(4-hydroxy-phenyl)-propionic acid is relatively safe under general operating conditions. However, it is still necessary to take appropriate laboratory safety measures, such as wearing protective glasses and gloves, and to ensure that the operation is carried out in a well-ventilated area. Care should be taken to avoid contact with skin and inhalation of gas or dust during use, and to properly dispose of waste. If a more detailed understanding of the toxicity or danger of the compound is required, reference should be made to the relevant safety data form or consult a professional body.