Name | Atropine |
Synonyms | ATROPINE Atropine atropine usp DL-Hyoscyamine Atropine solution atropine methanol solution atropine free base crystalline Benzeneaceticacid, α-(hydroxymethyl)-(3-endo)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate beta-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester (±)-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl ester Hyoscyamine, Tropine tropate, endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester |
CAS | 51-55-8 |
EINECS | 200-104-8 |
InChI | InChI=1/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16? |
InChIKey | RKUNBYITZUJHSG-SPUOUPEWSA-N |
Molecular Formula | C17H23NO3 |
Molar Mass | 289.37 |
Density | 1.0470 (rough estimate) |
Melting Point | 115-118°C |
Boling Point | 431.53°C (rough estimate) |
Flash Point | 2℃ |
Water Solubility | 1.6g/L(18 ºC) |
Solubility | H2O: 2mg/mL |
Vapor Presure | 0mmHg at 25°C |
Appearance | powder |
Color | white |
Merck | 14,875 |
BRN | 91260 |
pKa | 9.7(at 21℃) |
Storage Condition | -20°C |
Sensitive | Light Sensitive |
Refractive Index | 1.5200 (estimate) |
Physical and Chemical Properties | This product is racemic, its left-handed body is hyoscyamine. White crystals or powder, anhydrous melting point of 195-196 °c. Soluble in water, alcohol. Its aqueous solution is a neutral reaction. Is an anticholinergic that blocks the M-choline receptor. |
Use | For the rescue of septic shock, organophosphorus pesticide poisoning, relieve visceral colic, medication before anesthesia and reduce bronchial mucus secretion; Also used in Ophthalmology to make mydriasis or keratitis, iridocyclitis treatment. |
Risk Codes | R26/28 - Very toxic by inhalation and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R11 - Highly Flammable |
Safety Description | S25 - Avoid contact with eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
UN IDs | 1544 |
WGK Germany | 3 |
RTECS | CK0700000 |
FLUKA BRAND F CODES | 8-10-23 |
TSCA | Yes |
HS Code | 29399900 |
Hazard Class | 6.1 |
Packing Group | III |
Toxicity | LD50 orally in rats: 750 mg/kg (Cahen, Tvede) |
Raw Materials | Furan |