Molecular Formula | C29H42O10 |
Molar Mass | 550.64 |
Density | 1.41±0.1 g/cm3 (20 ºC 760 Torr) |
Melting Point | 238-239℃ (water ) |
Boling Point | 542°C (rough estimate) |
Specific Rotation(α) | D22 -1.7 ± 3° (c = 0.65 in methanol); D25 -9.4 ± 3° (c = 0.72 in dioxane) |
Flash Point | 247.1°C |
Solubility | Soluble in alcohol and acetone, slightly soluble in water and chloroform, almost insoluble in ether and petroleum ether. |
Vapor Presure | 1.8E-26mmHg at 25°C |
Appearance | White crystalline powder |
Merck | 13,2538 |
pKa | 13.04±0.70(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.5376 (estimate) |
MDL | MFCD00069477 |
Physical and Chemical Properties | White crystalline powder. Melting point 235-242 ℃. Soluble in alcohol and acetone, slightly soluble in water and chloroform, almost insoluble in ether and petroleum ether. |
In vitro study | Convallatoxin induces HaCaT cell necroptosis. |
In vivo study | Convallatoxin exerts antipsoriatic activities in two mouse models of psoriasis. |
UN IDs | 3249 |
WGK Germany | 2 |
RTECS | GL4025000 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 in mice, rats (mg/kg): 10.0 i.p., 16.0 i.v. (Frster) |
Reference Show more | 1. Zhang, Zhi Hong, et al. "Convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer." Phytomedicine 68 (2020): 153172.https://doi.or 2. [IF=4.268] Zhi Hong Zhang et al."Convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer."Phytomedicine. 2020 Mar;68:153172 3. [IF=8.739] Yue Xing et al.Convallatoxin inhibits IL-1β production by suppressing zinc finger protein 91-mediated pro-IL-1β ubiquitination and caspase-8 inflammasome activity.British Journal Of Pharmacology.2021 Nov 26 |