5-Bromo-1-oxo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
tert-Butyl 5-bromo-1-oxoisoindoline-2-carboxylate
CAS: 864866-80-8
Molecular Formula: C13H14BrNO3
5-Bromo-1-oxo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester - Names and Identifiers
5-Bromo-1-oxo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester - Physico-chemical Properties
| Molecular Formula | C13H14BrNO3 |
| Molar Mass | 312.16 |
| Storage Condition | Room Temprature |
| Sensitive | IRRITANT |
| MDL | MFCD17392825 |
5-Bromo-1-oxo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester - Introduction
tert-Butyl is an organic compound with the chemical formula C13H14BrNO3.
Nature:
-Appearance: Usually colorless or yellowish solid.
-Melting point: about 70-75°C.
-Boiling point: about 320°C.
-Solubility: Soluble in common solvents such as ethanol, methanol and dimethylformamide.
Use:
tert-Butyl is an important organic synthesis intermediate, commonly used in the synthesis of indole drugs and related compounds. It can be used as a raw material for the synthesis of fungicides, insecticides, acaricides and other biologically active compounds.
Preparation Method:
The synthesis of tert-Butyl usually includes the following steps:
1. Bromination reaction of indole: hydrogen atom on indole is substituted with bromine atom by using phosphorus tribromide (PBr3).
2. Carboxybenzylation reaction: a reaction using bromoindole and benzyl magnesium bromide to introduce a carboxyl group into a pyrrole ring.
3. tert-Butyl ketonization reaction: Under alkaline conditions, the hydroxyl group is converted to tert-butyl ester using tert-butyl catechol ester.
Safety Information:
tert-Butyl is likely to have a certain degree of irritation. During the operation, appropriate personal protective measures should be taken, such as wearing protective glasses and gloves. At the same time, it should be operated under well-ventilated conditions to avoid inhalation of dust or vapor of the compound. If ingested, contact with the skin or inhalation, should immediately seek medical treatment.
Nature:
-Appearance: Usually colorless or yellowish solid.
-Melting point: about 70-75°C.
-Boiling point: about 320°C.
-Solubility: Soluble in common solvents such as ethanol, methanol and dimethylformamide.
Use:
tert-Butyl is an important organic synthesis intermediate, commonly used in the synthesis of indole drugs and related compounds. It can be used as a raw material for the synthesis of fungicides, insecticides, acaricides and other biologically active compounds.
Preparation Method:
The synthesis of tert-Butyl usually includes the following steps:
1. Bromination reaction of indole: hydrogen atom on indole is substituted with bromine atom by using phosphorus tribromide (PBr3).
2. Carboxybenzylation reaction: a reaction using bromoindole and benzyl magnesium bromide to introduce a carboxyl group into a pyrrole ring.
3. tert-Butyl ketonization reaction: Under alkaline conditions, the hydroxyl group is converted to tert-butyl ester using tert-butyl catechol ester.
Safety Information:
tert-Butyl is likely to have a certain degree of irritation. During the operation, appropriate personal protective measures should be taken, such as wearing protective glasses and gloves. At the same time, it should be operated under well-ventilated conditions to avoid inhalation of dust or vapor of the compound. If ingested, contact with the skin or inhalation, should immediately seek medical treatment.
Last Update：2024-04-09 21:11:58
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Spot supply
Product Name: tert-Butyl 5-bromo-1-oxoisoindoline-2-carboxylate Visit Supplier Webpage Request for quotationCAS: 864866-80-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
5-Bromo-1-oxo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Dimethyl 1,3-acetonedicarboxylate
(R)-2-[(Aminoacetyl)amino]propionic acid
1-Piperidinecarbothioamide,N-cyclohexyl-3-(5-methyl-1H-benzimidazol-2-yl)-(9CI)
5-BROMO-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE
N-[2-(Diethyl-d10)aminoethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Fmoc-L-Cys(STmp)-OH
BUTYL 4-HYDROXYBENZOATE SODIUM SALT
N-[2-oxo-2-(piperidin-1-yl)ethyl]methanesulfonami de
Hexyl nicotinate
Dimethyl 1,3-acetonedicarboxylate
(R)-2-[(Aminoacetyl)amino]propionic acid
1-Piperidinecarbothioamide,N-cyclohexyl-3-(5-methyl-1H-benzimidazol-2-yl)-(9CI)
5-BROMO-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE
N-[2-(Diethyl-d10)aminoethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Fmoc-L-Cys(STmp)-OH
BUTYL 4-HYDROXYBENZOATE SODIUM SALT
N-[2-oxo-2-(piperidin-1-yl)ethyl]methanesulfonami de
Hexyl nicotinate