Name | 5-(Aminomethyl)-2-chloropyridine |
Synonyms | 6-Chloro-3-picolylamine 2-CHLORO-5-AMINOMETHYLPYRIDINE 6-chloro-3-pyridinemethanamine 5-AMINOMETHYL-2-CHLOROPYRIDINE 6-CHLORO-3-PYRIDINEMETHYLAMINE 3-AMINOMETHYL-6-CHLORO PYRIDINE (6-chloro-3-pyridyl)methanamine 5-(Aminomethyl)-2-chloropyridine 3-Pyridinemethanamine, 6-chloro- (6-CHLOROPYRIDIN-3-YL)METHANAMINE (6-CHLOROPYRIDIN-3-YL)METHYLAMINE 1-(6-chloropyridin-3-yl)methanamine 1-(6-CHLOROPYRIDIN-3-YL)METHANAMINE |
CAS | 97004-04-1 |
EINECS | 619-497-6 |
InChI | InChI=1/C6H7ClN2/c7-6-2-1-5(3-8)4-9-6/h1-2,4H,3,8H2 |
InChIKey | XPARFBOWIYMLMY-UHFFFAOYSA-N |
Molecular Formula | C6H7ClN2 |
Molar Mass | 142.59 |
Density | 1.244±0.06 g/cm3(Predicted) |
Melting Point | 28-34 °C |
Boling Point | 101-102°C 1mm |
Flash Point | >230°F |
Vapor Presure | 0.0175mmHg at 25°C |
BRN | 8308740 |
pKa | 7.78±0.29(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Sensitive | Hygroscopic |
Refractive Index | 1.571 |
MDL | MFCD00673153 |
Physical and Chemical Properties | This product is colorless oil, crystallized when cooled, m.p.25 ~ 26 ℃, B. p.82 ~ 84 ℃/53pa,n13D 1.5625, insoluble in water, soluble in toluene, benzene and other solvents. |
Risk Codes | R25 - Toxic if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R43 - May cause sensitization by skin contact R34 - Causes burns |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S20 - When using, do not eat or drink. |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
Hazard Class | 8 |
Packing Group | III |
Use | 2-chloro-5-aminomethylpyridine is an intermediate of the insecticide acetamiprid. |
production method | There are several preparation methods. The product can be obtained by reacting 2-chloro-5-aminomethylpyridine with hexamethylenetetramine in acetonitrile and methanol. With 2-chloro-5-chloromethylpyridine as raw material, add to the solution of potassium phthaloyl ammonium in DMF, heating reflux, cooling, add water to obtain N-(2-chloro-pyridin-5-yl-methyl) phthalamide, then hydrazine hydrate, methanol, heating reflux, after post-treatment product. With 2-chloro-5-cyanomethylpyridine, ethanol, ammonia and catalyst Raney nickel as raw materials, hydrogenation was carried out at room temperature and atmospheric pressure, hydrogenation was completed, filtration was carried out, and the filtrate was distilled under vacuum, the residue was added with toluene, dried over Na2SO4, and the toluene was removed by vacuum distillation. The product was distilled under reduced pressure. |