5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride

5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride - Names and Identifiers

Name	5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride
Synonyms	5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride 5-(piperazin-1-yl)benzofuran-2-carboxaMide hydrochloride 5-piperazin-1-yl-1-benzofuran-2-carboxamide,hydrochloride 1-(2-Aminocarbonylbenzofuran-5-yl)piperazine hydrochloride 5-Piperazin-1-yl-benzofuran-2-carboxylic acid aMide hydrochloride
CAS	913730-87-7

5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride - Physico-chemical Properties

Molecular Formula	C13H16ClN3O2
Molar Mass	281.73804
Storage Condition	2-8℃

5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride - Introduction

5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride(5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride) is an organic compound which is in the form of a hydrochloride salt. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: Usually white crystalline powder.
-Solubility: Soluble in water and some organic solvents, such as methanol and chloroform.
-Melting point: about 186-187°C.
-Molecular formula: C14H15N3O2 · HCl.
-Molecular weight: about 307.75.

Use:
-Pharmaceutical Field: 5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride is often used as a pharmaceutical intermediate. It can be used to synthesize biologically active compounds such as antidepressants and neuromodulators.

Method:
The preparation of -5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride can be completed by the following steps:
1. First, benzofuranone reacts with 2-amino acetic anhydride to generate ethyl 2-benzofuran formate.
2. Next, ethyl 2-benzofurancarboxylate is reacted with piperazine to obtain ethyl 5-(1-piperazinyl)-2-benzofurancarboxylate.
3. Finally, ethyl 5-(1-piperazinyl)-2-benzofurancarboxylate is reacted with hydrogen chloride to generate 5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride.

Safety Information:
- 5-(1-Piperazinyl)-2-benzofurancarboxamide hydrochloride has good safety under normal use conditions.
-However, as a chemical substance, it may have a certain impact on human health.
-When using or handling the compound, care should be taken to comply with laboratory safety regulations.
-Avoid direct inhalation, ingestion or skin contact when in contact with this compound. If exposed, immediately flush the affected area with clean water and seek medical assistance.
-In addition, when storing and handling the compound, keep it away from ignition and oxidizing agents, and keep it properly.

Last Update：2024-04-09 21:01:54