Name | 5'-isobutylthio-5'-deoxyadenosine |
Synonyms | SIBA 5'-Isobutylthioadenosine 5'-ISOBUTYLTHIOADENOSINE 5'-S-Isobutyl-5'-deoxyadenosine 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE 5'-isobutylthio-5'-deoxyadenosine 5'-DEOXY-5'-ISOBUTYLTHIOADENOSINE 5'-Deoxy-5'-isobutylthioadenosine 5'-deoxy-5'-s-isobutylthioadenosine 5'-S-(2-Methylpropyl)-5'-thioadenosine |
CAS | 35899-54-8 |
InChI | InChI=1/C14H21N5O3S/c1-7(2)3-23-4-8-10(20)11(21)14(22-8)19-6-18-9-12(15)16-5-17-13(9)19/h5-8,10-11,14,20-21H,3-4H2,1-2H3,(H2,15,16,17)/t8-,10-,11-,14-/m1/s1 |
Molecular Formula | C14H21N5O3S |
Molar Mass | 339.41 |
Density | 1.63±0.1 g/cm3(Predicted) |
Boling Point | 631.2±65.0 °C(Predicted) |
Flash Point | 335.5°C |
Vapor Presure | 8.43E-17mmHg at 25°C |
pKa | 13.13±0.70(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
Refractive Index | 1.752 |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.946 ml | 14.731 ml | 29.462 ml |
5 mM | 0.589 ml | 2.946 ml | 5.892 ml |
10 mM | 0.295 ml | 1.473 ml | 2.946 ml |
5 mM | 0.059 ml | 0.295 ml | 0.589 ml |
Biological activity | SIBA (5 '-Isobutylthioadenosine) is a synthetic analog of S-adenosine homocysteine (SAH, HY-19528), which can inhibit SAH-mediated transmethylation. SIBA can interfere with a variety of enzyme activities in vitro, such as SAH hydrolase, methyl thioadenosine phosphorylase and cAMP phosphodiesterase. SIBA reversibly inhibits the proliferation of herpes simplex virus type 1 (HSV). |