5′-核苷酸酶
5′-NT
CAS: 9027-73-0
Molecular Formula:
5′-核苷酸酶 - Names and Identifiers
| Name | 5′-NT |
| Synonyms | NTE NT5 5′-NT Nucleotidase, 5'- 5′-Nucleotidase human 5'-NUCLEOTIDASE FROM CROTALUS ATROX VENOM* 5'-nucleotidase from crotalus adamanteus venom ANTI-CD73 (NT5E)(C-TERMINAL) antibody produced in rabbit |
| CAS | 9027-73-0 |
| EINECS | 232-820-1 |
5′-核苷酸酶 - Physico-chemical Properties
| Appearance | Freeze-dried white powder |
| Storage Condition | −20°C |
| MDL | MFCD00130311 |
| Use | Tool enzymes in nucleic acid research are necessary tool enzymes in nucleic acid structure analysis. 5 '-NT is a specific phosphohydrolase that catalyzes the hydrolysis of 5'-nucleotides. |
5′-核苷酸酶 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-18 |
| HS Code | 35079090 |
5′-核苷酸酶 - Reference
| Reference Show more | 1. [IF=7.514] Zhiyong Zhang et al."Umami taste and its association with energy status in harvested Pleurotus geesteranus stored at different temperatures."Food Chem. 2019 May;279:179 2. [IF=7.514] Saili Zhang et al."Effects of negative air ions treatment on the quality of fresh shiitake mushroom (Lentinus edodes) during storage."Food Chem. 2022 Mar;371:131200 3. [IF=4.952] Shiya Ren et al."Evaluation of physicochemical properties, equivalent umami concentration and antioxidant activity of Coprinus comatus prepared by different drying methods."LWT-FOOD SCIENCE AND TECHNOLOGY. 2022 Jun;162:113479 |
5′-核苷酸酶 - Vitality definition
One unit will hydrolyze 1.0 μmole of inorganic phosphorus from adenosine 5′-monophosphate per min at pH 9.0 at 37℃。
Last Update：2023-08-16 21:32:38
5′-核苷酸酶 - Vitality
≥50 units/mg protein。
Last Update：2023-08-16 21:32:38
5′-核苷酸酶 - Reference Information
| Overview | 5 '-nucleotidase (5'- Nucleotidase,5 '- NT) is a hydrolase with low substrate specificity and can act on a variety of nucleotides. It is composed of 2 identical subunits, each subunit has a molecular weight of 70kD, a hydrophobic group and an enzyme catalytic active center outside the cell membrane surface. Widely exists in the human liver and various tissues, located on the cell membrane, and mainly exists in the bile duct and sinus space membrane in the liver. |
| clinical | 5 '-NT determination in serum is mainly used for diagnosis of hepatobiliary system diseases and differential diagnosis of bone diseases. The increase of 5 '-NT activity in serum is mainly seen in hepatobiliary system diseases, such as obstructive jaundice, primary and secondary liver cancer, hepatitis, etc., and its activity changes are usually consistent with the activity of ALP. In skeletal diseases, such as tumor metastasis, osteitis deformity, hyperparathyroidism, rickets, etc., ALP activity is usually increased, but 5 '-NT is normal. Therefore, the simultaneous determination of ALP and 5 '- NT is helpful for the differential diagnosis of hepatobiliary system and skeletal system diseases. |
| Use | 5 '-nucleotide enzyme (5'-NT) is a hydrolase with low substrate specificity and can act on a variety of nucleotides. This enzyme is mainly derived from the liver and widely exists in human tissues, such as liver, gallbladder, intestine, brain, heart, pancreas, etc. Located on the cytoplasmic membrane, this enzyme mainly exists in the bile duct and sinus space membrane in the liver. The determination of 5 '-NT is mainly colorimetric, which is troublesome to operate and difficult to automate, but reagents are easily available and suitable for application in grass-roots units. |
Last Update：2024-04-09 21:54:55
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View History
5′-核苷酸酶
西格列汀 N-磷酸酯杂质
C.I.酸性黑52(第一组成部分)
Bis(2-aminophenyl) ether
甲基 2-(((苄氧基)羰基)氨基)-7-氧亚基-6-氮杂螺[3.4]辛烷-8-甲酸基酯
AMMONIUM TITANYL OXALATE
C.I.Vat Red 15
TOSLAB 837277
4-甲氧基呋喃并[3,2-D]嘧啶-6-羧酸
地美罗酸镁盐
西格列汀 N-磷酸酯杂质
C.I.酸性黑52(第一组成部分)
Bis(2-aminophenyl) ether
甲基 2-(((苄氧基)羰基)氨基)-7-氧亚基-6-氮杂螺[3.4]辛烷-8-甲酸基酯
AMMONIUM TITANYL OXALATE
C.I.Vat Red 15
TOSLAB 837277
4-甲氧基呋喃并[3,2-D]嘧啶-6-羧酸
地美罗酸镁盐