4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride
Forodesine hydrochloride
CAS: 284490-13-7
Molecular Formula: C11H15ClN4O4
4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride - Names and Identifiers
4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride - Physico-chemical Properties
| Molecular Formula | C11H15ClN4O4 |
| Molar Mass | 302.72 |
| Melting Point | 268-270°C |
| Solubility | Soluble in DMSO |
| Appearance | Solid |
| Color | Off-White to Pale Beige |
| Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
| Stability | Hygroscopic |
| Use | Forodesine hydrochloride is a transition-state analog inhibitor of purine nucleoside phosphorylase. |
4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride - Reference
| Reference Show more | 1: Argnani L, Broccoli A, Zinzani PL. Cutaneous T-cell lymphomas: Focusing on novel agents in relapsed and refractory disease. Cancer Treat Rev. 2017 Dec;61:61-69. doi: 10.1016/j.ctrv.2017.10.007. Epub 2017 Oct 28. Review. PubMed PMID: 29102679. 2: Lewis DJ, Duvic M. Forodesine in the treatment of cutaneous T-cell lymphoma. Expert Opin Investig Drugs. 2017 Jun;26(6):771-775. doi: 10.1080/13543784.2017.1324569. Epub 2017 May 5. Review. PubMed PMID: 28447489. 3: Thomas X, Le Jeune C. Treating adults with acute lymphocytic leukemia: new pharmacotherapy options. Expert Opin Pharmacother. 2016 Dec;17(17):2319-2330. Epub 2016 Oct 31. Review. PubMed PMID: 27759440. 4: Freitas EO, Nico D, Alves-Silva MV, Morrot A, Clinch K, Evans GB, Tyler PC, Schramm VL, Palatnik-de-Sousa CB. Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis. PLoS Negl Trop Dis. 2015 Dec 23;9(12):e0004297. doi: 10.1371/journal.pntd.0004297. eCollection 2015 Dec. PubMed PMID: 26701750; PubMed Central PMCID: PMC4689457. |
4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.303 ml | 16.517 ml | 33.034 ml |
| 5 mM | 0.661 ml | 3.303 ml | 6.607 ml |
| 10 mM | 0.33 ml | 1.652 ml | 3.303 ml |
| 5 mM | 0.066 ml | 0.33 ml | 0.661 ml |
Last Update：2024-01-02 23:10:35
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View History
4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride
Propionyl 3,4,6-Tri-O-acetyl-2-acetamido-2-deoxy-β-D-thiogalactopyranoside
800409-46-5
374707-77-4
1881288-99-8
1H-Pyrrole-3-carboxylic acid, 2-amino-1-methyl-, ethyl ester
50903-75-8
921487-24-3
CPD1217
N-allylprop-2-en-1-amine
Propionyl 3,4,6-Tri-O-acetyl-2-acetamido-2-deoxy-β-D-thiogalactopyranoside
800409-46-5
374707-77-4
1881288-99-8
1H-Pyrrole-3-carboxylic acid, 2-amino-1-methyl-, ethyl ester
50903-75-8
921487-24-3
CPD1217
N-allylprop-2-en-1-amine