Name | Stiripentol |
Synonyms | bcx2600 Diacomit 256-480-9 Stiripentol STIRIPENTOL 1-(1,3-BENZODIOXOL-5YL)-4,4-DIMETHYL-1-PENTEN-3-OL 1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-o 1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol 4,4-dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-o 4,4-dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-ol (1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol (RS)-(E)-4,4-dimethyl-1-[3,4(methylenedioxy)-phenyl]-1-penten-3-ol |
CAS | 49763-96-4 |
EINECS | 256-480-9 |
InChI | InChI=1/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+ |
InChIKey | IBLNKMRFIPWSOY-FNORWQNLSA-N |
Molecular Formula | C14H18O3 |
Molar Mass | 234.29 |
Density | 1.139±0.06 g/cm3(Predicted) |
Melting Point | 73-74°C |
Boling Point | 365.4±11.0 °C(Predicted) |
Flash Point | 174.8°C |
Solubility | DMSO: ≥20mg/mL |
Vapor Presure | 5.54E-06mmHg at 25°C |
Appearance | powder |
Color | white to beige |
pKa | 14.45±0.20(Predicted) |
Storage Condition | -20°C |
Refractive Index | 1.578 |
Use | This product is for scientific research only and shall not be used for other purposes. |
In vitro study | Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to N-desmethylclobazam (NCLB) mediated by CYP3A4 (noncompetitively) and CYP2C19 (competitively). The inhibition of CLB demethylation by Stiripentol (STP) is best described by a noncompetitive inhibition model with apparent K i =1.6 μM for the cDNA-expressing CYP3A4 and by a competitive inhibition model with K i =0.52 μM for the cDNA-expressing CYP2C19. Formation of OH-NCLB from NCLB by cDNA-expressing CYP2C19 is competitively inhibited by Stiripentol (STP) with a K i =0.14 μM. |
In vivo study | In mice treating with Stiripentol (STP) monotherapy, the difference between BT 1 (39.67±1.09°C) and BT 2 (41.32±1.05°C) reaches statistical significance (t=3.097, p<0.05). The difference in BT 2 between Stiripentol (STP) monotherapy and CLB monotherapy is statistically significant (t=2.615, p<0.05). In mice treating with Stiripentol (STP)+CLB combination therapy, the difference between BT 1 (40.18±0.58°C) and BT 2 (43.03±0.49°C) reaches statistical significance (t=10.44, p<0.01). |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
WGK Germany | 3 |
RTECS | SB3393000 |