49757-42-8 - Names and Identifiers
Name | 4,4',4''-trimethoxytrityl chloride
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Synonyms | Trimethoxy trityl chloride 4,4',4''-trimethoxytrityl chloride 4,4',4''-TRIMETHOXYTRITYL CHLORIDE 4,4',4''-TRIMETHOXYTRITYL CHLORIDE, TECH . 4,4',4''-trimethoxytriphenylmethyl chloride 4,4',4''-(Chloromethanetriyl)tris(methoxybenzene) 1,1',1''-(chloromethylidyne)tris[4-methoxy-benzen 4,4',4''-Trimethoxytrityl chloride technical grade 1,1',1''-(chloromethanetriyl)tris(4-methoxybenzene) Chlorotris(4-methoxyphenyl)methane~4,4,4-Trimethoxytriphenylmethyl chloride
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CAS | 49757-42-8
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EINECS | 256-474-6 |
InChI | InChI=1/C22H21ClO3/c1-24-19-10-4-16(5-11-19)22(23,17-6-12-20(25-2)13-7-17)18-8-14-21(26-3)15-9-18/h4-15H,1-3H3 |
49757-42-8 - Physico-chemical Properties
Molecular Formula | C22H21ClO3
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Molar Mass | 368.85 |
Density | 1.166±0.06 g/cm3(Predicted) |
Melting Point | 146-148°C(lit.) |
Boling Point | 497.8±45.0 °C(Predicted) |
Flash Point | 160.7°C |
Vapor Presure | 1.48E-09mmHg at 25°C |
BRN | 892836 |
Storage Condition | Store at 0-5°C |
Sensitive | Moisture Sensitive |
Refractive Index | 1.574 |
MDL | MFCD00008408 |
49757-42-8 - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
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WGK Germany | 3 |
HS Code | 29093090 |
49757-42-8 - Introduction
4,4 ',4 ''-trimethoxytrityl chloride(4,4',4''-trimethoxytrityl chloride) is an organic compound with the following characteristics:
-Appearance: 4,4 ',4 ''-trimethoxytrityl chloride as a white crystalline solid.
-Solubility: Soluble in organic solvents, such as chlorinated hydrocarbons, alcohols, ethers, etc.
-Melting point: The melting point is about 65-68 degrees Celsius.
4,4 ',4 ''-trimethoxytrityl chloride are mainly used for protecting groups in organic synthesis. Common applications include:
-Used as a protecting group: It can be used as a protecting chlorination reagent to protect reactive sites such as amino and hydroxyl groups to prevent accidental damage during the reaction. In organic synthesis, by adding 4,4 ',4 "-trimethoxytrityl chloride, the target group of the compound can be protected, thereby improving the selectivity during the synthesis.
-Used for synthetic pigments: 4,4 ',4 ''-trimethoxytrityl chloride can also be used for synthetic dyes and fluorescent dyes.
4,4 ',4 ''-trimethoxytrityl chloride is prepared as follows:
First, 4,4 ',4'-trimethoxybenzyl ether is reacted with thionyl chloride to form 4,4 ',4'-trimethoxybenzyl sulfoxide. This compound is subsequently reacted with ferrous chloride and then treated with hydrogen chloride to give the final product 4,4 ',4 "-trimethoxytrityl chloride.
For safety information about the 4,4 ',4 ''-trimethoxytrityl chloride, please note the following:
- 4,4 ',4 ''-trimethoxytrityl chloride is an irritating compound that may cause irritation on contact with skin and eyes. Appropriate personal protective measures should be taken during operation, such as wearing gloves and goggles.
-It is also a flammable substance and should be stored in a cool, dry place, away from fire and oxidants.
-operation should avoid inhalation of its vapor, need to operate in a well-ventilated place. In case of accidental inhalation, immediately move to a place with fresh air and seek medical assistance.
When using and handling 4,4 ',4 ''-trimethoxytrityl chloride, please be sure to carefully read and follow the relevant chemical safety procedures, and operate under the guidance of professionals.
Last Update:2024-04-09 18:58:34