Molecular Formula | C20H17NO6 |
Molar Mass | 367.35 |
Density | 1.3694 (rough estimate) |
Melting Point | 193-197 °C |
Boling Point | 497.92°C (rough estimate) |
Specific Rotation(α) | D25 +130.5° (CHCl3) |
Flash Point | 281.8°C |
Solubility | Soluble in benzene, chloroform, ethyl acetate, slightly soluble in ethanol and ether. |
Vapor Presure | 7.98E-12mmHg at 25°C |
Appearance | Slender flake crystal |
Color | Pale Yellow |
Maximum wavelength(λmax) | ['325nm(lit.)'] |
Merck | 14,1203 |
BRN | 98786 |
pKa | 4.84(at 25℃) |
Storage Condition | 2-8°C |
Refractive Index | 1.5600 (estimate) |
MDL | MFCD00005006 |
Physical and Chemical Properties | Melting point 196-198°C. |
In vitro study | (+)-Bicuculline (1-100 μm) inhibits Cl produced by 40 μm GABA In addition to being A potent GABA A receptor antagonist, (+)-Bicuculline also inhibits Ca |
Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R50 - Very Toxic to aquatic organisms R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
UN IDs | UN 1544 6.1/PG 2 |
WGK Germany | 3 |
RTECS | LV0909840 |
FLUKA BRAND F CODES | 10-23 |
HS Code | 29399990 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 ipr-mus: 8480 mg/kg CUTOEX 1,199,93 |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
effect | bicuculide has analgesic, sedative, anti-cancer and antispasmodic effects of intestinal smooth muscle. It has been reported that bicuculide has certain proliferation inhibitory effects on human GLC cells, human uterine cancer HeLa cells and KB cells. In addition, bicuculide has certain anti-tumor effects on human lung adenocarcinoma cell A549. |
Biological activity | ( )-Bicuculline (d-Bicuculline) is a competitive GABAA receptor antagonist with an IC50 of 2 μM, which also inhibits Ca(2) Activated potassium channels. |
Target | Value |
GABAA receptor | 2 μM |
use | GABAA receptor competitive antagonist is an important tool for studying GABAergic synaptic transmission GABAA receptor competitive antagonist is an important tool for studying GABAergic synaptic transmission. |
category | pesticide |
toxicity classification | highly toxic |
acute toxicity | abdominal cavity-mouse LD50: 8.48 mg/kg |
flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxides smoke dance |
storage and transportation characteristics | ventilation and low temperature drying; separate from warehouse food raw materials |
fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |