Name | Indigo |
Synonyms | Indigo C.I. 73000 d+cblueno6 Vat Blue 1 Indigo blue D+C Blue No. 6 PIGMENT BLUE 66 C.I. Vat Blue 1 (2,2'-Biindoline)-3,3'-dione (2,2'-biindoline)-3,3'-dione 2,2'-biindole-3,3'(1H,1'H)-dione (delta(2,2')-biindoline)-3,3'-dione 2,2'-Bis(2,3-dihydro-3-oxoindolylidene) (delta(2,2'(3h,3'h))-biindole)-3,3'-dione 2-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one |
CAS | 482-89-3 |
EINECS | 207-586-9 |
InChI | InChI=1/C16H10N2O2/c19-15-9-5-1-3-7-11(9)17-13(15)14-16(20)10-6-2-4-8-12(10)18-14/h1-8,17-18H |
InChIKey | COHYTHOBJLSHDF-BUHFOSPRSA-N |
Molecular Formula | C16H10N2O2 |
Molar Mass | 262.26 |
Density | 1.01g/mLat 20°C |
Melting Point | >300°C(lit.) |
Boling Point | 405.51°C (rough estimate) |
Flash Point | >220℃ |
Water Solubility | <0.1 g/100 mL |
Solubility | DMSO (Slightly, Heated, Sonicated), DMF (Slightly) |
Vapor Presure | 0Pa at 100℃ |
Appearance | Blue powder |
Color | Dark blue to violet |
Merck | 14,4943 |
BRN | 88275 |
pKa | -3.83±0.20(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Stability | Stable. Incompatible with strong oxidizing agents. |
Refractive Index | 1.5800 (estimate) |
MDL | MFCD00005722 |
Physical and Chemical Properties | Melting point 390-392°C (dec.) water-soluble <0.1g/100 mL hue or shade: Blue |
Use | Mainly used for cotton, cotton, wool or silk dyeing The pigment is an important vat dye indigo pigment processing products, with excellent light resistance, the color fastness to climate and heat stability give a blue tone, and can be used to prepare a liquid dispersion dosage form, mainly used in viscose fiber pulp coloring and printing and dyeing. |
Risk Codes | R36/38 - Irritating to eyes and skin. R36/37/38 - Irritating to eyes, respiratory system and skin. R48/20/21/22 - |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
UN IDs | UN 3264 8/PG 3 |
WGK Germany | 1 |
RTECS | DU2988400 |
HS Code | 32041510 |
Toxicity | LD50 oral in mouse: > 32gm/kg |
Raw Materials | Aniline Chloroacetic acid Potassium hydroxide Sodium hydroxide Ammonia Chloroacetic acid Sodium |
Reference Show more | 1. Cheng Pei, Xia Ye, Fang Yu et al. Determination of indigo and indirubin in horse Blue from different habitats and different medicinal parts [J]. Medical leads 2015(10):1363. 2. Xiao Yinghua Xia Ye Cheng Pei et al. Simultaneous determination of indigo and indirubin in folium isatidis by RP-HPLC [J]. Medical leads 2015 34(11):1506-1508. 3. Chang Baoqin, Li Meimei, Hui Huaji, etc. Extraction and analysis of alkaloid indigo and indirubin from Radix isatidis [J]. Agricultural science and technology and information, 2019, 000(022):40-43. 4. Kongshujia, Yanwen Li. Determination of indigo in rat plasma by liquid chromatography-tandem mass spectrometry and its pharmacokinetics [J]. China Pharmacy, 2017, 28(007):912-915. 5. Li Haiyi, Li Yanguang, Liang Qingyun, et al. Comparison of extraction and content of indigo and indirubin in leaves and roots of Isatis indigotica [J]. Guangdong Chemical Industry, 2016, 43(02):27-28. 6. Liang Zhenbao, Li Haiyi, Li Yanguang, etc. Studies on the effective components in the root, stem and leaf of Isatis indigotica [J]. Guangzhou Chemical Industry, 2016(11):156-157. 7. Li Xiao-Chen, Wei Wei, Zhang Jian-Yu, Li Li, cow bud. Study on correlation between starch content and active component content in radix isatidis [J]. Chemical Engineer, 2020,34(07):24-26 16. 8. Zhang Yiming, Wan Hui Hua, Su Yong, Lu Meng, Yang Wei, Zhi Junwen. Effects of frostbite bluish on the contents of four indolyl derivatives in broad-sense postrinus plants [J]. Journal of Northwest Botany, 2020,40(11):1951-1958. 9. [IF=4.411] Zhiqin Xu et al."Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents."Molecules. 2021 Jan;26(6):1729 10. [IF=4.162] Jiuling Deng et al."A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica."Drug Des Dev Ther. 2021; 15: 3193-3206 11. [IF=2.984] Yi-Ming Zhang et al."Integration of the metabolome and transcriptome reveals indigo biosynthesis in Phaius flavus flowers under freezing treatment."Peerj. 2022 Mar;10:e13106 |