480438-83-3 - Names and Identifiers
Name | (2R)-3,3,3-trifluoro-2-[(2S)-tetrahydrothiophen-2-ylmethyl]propanoate
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Synonyms | 3,3,3-TRIFLUORO-(2-TETRAHYDROTHIENYLMETHYL)PROPIONIC ACID 2-Thiophenepropanoic acid, tetrahydro-α-(trifluoromethyl)- 3-(TETRAHYDROTHIOPHEN-2-YL)-2-TRIFLUOROMETHYLPROPIONIC ACID (2R)-3,3,3-trifluoro-2-[[(2R)-2-thiolanyl]methyl]propanoate 3,3,3-TRIFLUORO-2-(TETRAHYDROTHIEN-2-YLMETHYL)PROPANOIC ACID 3,3,3-Trifluoro-3-[(2-tetrahydrothienyl)methyl]propionic acid (2R)-3,3,3-trifluoro-2-[(2S)-tetrahydrothiophen-2-ylmethyl]propanoate 3,3,3-Trifluoro-(2-tetrahydrothienylmethyl)propionic acid, mixture of diastereomers
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CAS | 480438-83-3
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InChI | InChI=1/C8H11F3O2S/c9-8(10,11)6(7(12)13)4-5-2-1-3-14-5/h5-6H,1-4H2,(H,12,13)/p-1/t5-,6+/m0/s1 |
480438-83-3 - Physico-chemical Properties
Molecular Formula | C8H11F3O2S
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Molar Mass | 228.23 |
Density | 1.376g/mLat 25°C(lit.) |
Boling Point | 235°C(lit.) |
Flash Point | >230°F |
Vapor Presure | 0.000144mmHg at 25°C |
Storage Condition | Room Temprature |
Refractive Index | n20/D >1.4620(lit.) |
480438-83-3 - Risk and Safety
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin.
R22 - Harmful if swallowed
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Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
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WGK Germany | 3 |
HS Code | 29321900 |
Hazard Note | Irritant |
480438-83-3 - Introduction
(2R)-3,3,3-trifluoro-2-[(2S)-tetrahydrothiophen-2-ylmethyl]propanoate is an organic compound with the chemical formula C10H13F3O2S.
Nature:
-Appearance: colorless liquid
-Melting point:-40 ℃
-boiling point: 130-131 ℃
-Molecular weight: 260.29g/mol
Use:
(2R)-3,3,3-trifluoro-2-[(2S)-tetrahydrothiophen-2-ylmethyl]propanoate are usually used as catalysts or as intermediates in organic synthesis. It can be used to synthesize a variety of drugs, pesticides and polymer compounds. In addition, it can also be used as a surfactant, an organic solvent, and an antibacterial agent.
Preparation Method:
The preparation method of (2R)-3,3,3-trifluoro-2-[(2S)-tetrahydrothiophen-2-ylmethyl]propanoate usually involves the following steps:
1. In an appropriate solvent, 2-tetrahydrothiophene is reacted with trifluorocarboxylic anhydride to give trifluoro-formic acid-tetrahydrothiophene ester.
2. The trifluoro-formic acid-tetrahydrothiophene ester is then reacted with an appropriate reducing agent, such as hydrogen, sodium hydride, etc., to give 3,3, 3-trifluoro-3-[(2-tetrahydrothiophenethyl) methyl] propanol.
3. Finally, 3,3, 3-trifluoro-3-[(2-tetrahydrothiophenyl) methyl] propanol is reacted with an appropriate acid to obtain the target compound.
Safety Information:
Regarding the handling and storage of (2R)-3,3,3-trifluoro-2-[(2S)-tetrahydrothiophen-2-ylmethyl]propanoate, general laboratory safety practices need to be followed. It is an organic compound that may be irritating to the skin, eyes and respiratory system, so avoid contact with skin and eyes during operation, and ensure that it is operated in a well-ventilated place. After disposal, waste should be disposed of properly and in accordance with local regulations.
Last Update:2024-04-09 21:54:55