Name | betulin |
Synonyms | betulin Betuline Betulinol BETULIN(P) BETULIN hplc betula camphor Betulinic alcohol lup-20(29)-ene-3,28-diol 3b,28-Dihydroxylup-20(29)-ene Lup-20(29)-ene-3,28-diol, (3β)- (3beta)-lup-20(29)-ene-3,28-diol (3beta,5xi,9xi,18xi)-lup-20(29)-ene-3,28-diol (3beta,5xi,9xi,13xi,14xi,18xi,19xi)-lup-20(29)-ene-3,28-diol |
CAS | 473-98-3 |
EINECS | 207-475-5 |
InChI | InChI=1/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22?,23?,24-,25?,27-,28+,29+,30+/m0/s1 |
InChIKey | FVWJYYTZTCVBKE-ROUWMTJPSA-N |
Molecular Formula | C30H50O2 |
Molar Mass | 442.72 |
Density | 0.9882 (rough estimate) |
Melting Point | 256-257°C(lit.) |
Boling Point | 493.26°C (rough estimate) |
Specific Rotation(α) | D15 +20° (c = 2 in pyridine) |
Flash Point | 210.9°C |
Solubility | Soluble in ethanol, chloroform and benzene, slightly soluble in cold water, petroleum ether, etc. |
Vapor Presure | 4.32E-13mmHg at 25°C |
Appearance | White crystalline powder |
Color | Pale Brown to Beige |
Merck | 14,1189 |
pKa | 15.10±0.10(Predicted) |
Storage Condition | 2-8°C |
Stability | Hygroscopic |
Refractive Index | 1.5045 (estimate) |
MDL | MFCD00016802 |
Physical and Chemical Properties | Melting Point 256-257°C. |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R68/20/21/22 - R68 - Possible risk of irreversible effects |
Safety Description | S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | OK5755000 |
HS Code | 29181985 |
Reference Show more | 1. Jiang Yang Sun, Fei Fei, Yan Yaguang, et al. Effects of carbon monoxide on cell growth and triterpenoid accumulation in suspension cultures of Betula platyphylla [J]. Chinese herbal medicine 2019 v.50;No.650(15):170-175. 2. Liu Lu, Ren Yanhong, Zhang Jie, et al. Protective effects of betulin on adriamycin-induced cardiac damage in rats [J]. Journal of Toxicology, 2017, 06(v.31):47-50 54. 3. Ji Xin, Liu Xiaoqian, Gao Lu, Xiao Suping, Liang obanhua, Li Chun, Wang Zhiming. Qualitative and Quantitative Analysis of triterpenoids in fructus Ligustri Lucidi [J]. Chinese Journal of Traditional Chinese Medicine, 2021,46(05):1168-1178. 4. Han Yue, Li Zhanjun, Li Mengyuan, Yang Fengjian. Optimization of extraction of triterpenoids from Betula alnoides by response surface methodology [J]. Forest Engineering, 2021,37(02):79-85. 5. [IF = 3.978] Hongfei Yu et al."The effect of triterpenoid saponins on pancreatic lipase in vitro: Activity, conformation, kinetics, thermodynamics and morphology."Biochem Eng J. 2017 Sep;125:1 6. [IF=6.023] Li Ren et al."Anti-inflammatory action of betulin and its potential as a dissociated glucocorticoid receptor modulator."Food Chem Toxicol. 2021 Nov;157:112539 |