46049-48-3 - Names and Identifiers
Name | 1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanamine
|
Synonyms | (R)-2,3-dihydro-1,4-Benzodioxin-2-methanamine (R)-2-Aminomethyl-2,3-dihydro-benzo[1,4]dioxine (3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methanamine 1,4-benzodioxin-2-methanamine, 2,3-dihydro-, (2R)- (R)-2-(Aminomethyl)-2,3-dihydrobenzo[b][1,4]dioxine 1-[(2R)-2,3-Dihydro-1,4-benzodioxin-2-yl]methanamine (R)-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanamine 1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanamine
|
CAS | 46049-48-3
|
InChI | InChI=1/C9H11NO2/c10-5-7-6-11-8-3-1-2-4-9(8)12-7/h1-4,7H,5-6,10H2/t7-/m1/s1 |
46049-48-3 - Physico-chemical Properties
Molecular Formula | C9H11NO2
|
Molar Mass | 165.19 |
Density | 1.154g/cm3 |
Boling Point | 266°C at 760 mmHg |
Flash Point | 124.1°C |
Vapor Presure | 0.00885mmHg at 25°C |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 1.545 |
46049-48-3 - Introduction
1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanamine, also known as 1-[(2R)-2,3-dihydro-1,4-benzodioxan-2-yl] methylamine, is an organic compound. Its chemical formula is C10H13NO2.
Nature:
-Appearance: White crystalline solid
-melting point: 92-95 ℃
-Boiling point: 354 ℃ (decomposition)
-density: 1.22 g/cm ^ 3
-Solubility: Soluble in water and organic solvents such as chloroform, ethanol
Use:
1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanamine is mainly used for the synthesis of drugs, especially the enantioselective synthesis of drug intermediates. It can be used as chiral inducer, reducing agent, amino reagent, etc.
Preparation Method:
A commonly used preparation method is to react 2,3-dimethoxyphenyl ether with glutarimide to obtain 2,3-dimethoxy -1,4-benzodioxane. Then, 2,3-dimethoxy -1,4-benzodioxane is reacted with iminomethanol, which is reduced to give 1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanamine.
Safety Information:
Limited safety information is available for the 1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanamine. However, as a chemical, attention should be paid to the correct handling and storage methods, avoid contact with skin and eyes, and avoid inhalation or intake. Appropriate protective equipment should be worn during use to ensure good ventilation. In the event of an accident, appropriate first aid measures should be taken immediately and professional medical personnel should be consulted. Before handling and storage, it is recommended to consult the product safety data sheet for more detailed and up-to-date safety information.
Last Update:2024-04-09 15:17:58