46032-98-8 - Names and Identifiers
Name | (1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol
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Synonyms | (2R,3S)-PHENYLSERINOL (2R,3R)-3-PHENYLSERINOL (1R,2S)-3-Phenylserinol (1R,2R)-1-Phenyl-2-amino-1,3-propanediol (1R,2R)-2-AMINO-1-PHENYLPROPANE-1,3-DIOL (1S,2R)-2-amino-1-phenylpropane-1,3-diol (R(R*,R*))-2-Amino-1-phenylpropane-1,3-diol [R(R*,R*)]-2-amino-1-phenylpropane-1,3-diol (1R,2R)-(-)-2-AMINO-1-PHENYL-1,3-PROPANEDIOL (1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol (1R,2R)-1,3-dihydroxy-1-phenylpropan-2-aminium 1,3-Propanediol, 2-amino-1-phenyl-, [R-(R*,R*)]-
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CAS | 46032-98-8
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EINECS | 256-250-8 |
InChI | InChI=1/C9H13NO2/c10-8(6-11)9(12)7-4-2-1-3-5-7/h1-5,8-9,11-12H,6,10H2/p+1/t8-,9-/m1/s1 |
46032-98-8 - Physico-chemical Properties
Molecular Formula | C9H13NO2
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Molar Mass | 167.21 |
Density | 1.1222 (rough estimate) |
Melting Point | 112-118 °C (lit.) |
Boling Point | 295.79°C (rough estimate) |
Specific Rotation(α) | -39 º (c=1, 1N HCl) |
Flash Point | 171.9°C |
Vapor Presure | 7.87E-06mmHg at 25°C |
pKa | 11.73±0.45(Predicted) |
Refractive Index | -26.5 ° (C=1, MeOH) |
46032-98-8 - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
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UN IDs | UN 3259 8/PG 3 |
WGK Germany | 3 |
HS Code | 29221985 |
46032-98-8 - Introduction
(1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol ((1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol) is a chiral molecule whose chemical structure contains an amino group, a phenyl group and a propylene glycol group.
The compound is a white to white crystalline solid at room temperature and is soluble in water and inorganic acids. It has two chiral centers, so it exists four asymmetric isomers, of which (1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol is one of the optical isomers.
(1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol is widely used in chemical synthesis and pharmaceutical fields. It is an important chiral ligand and can be used as chiral inducer and chiral ligand in asymmetric catalytic reactions. In addition, it can also be used in the synthesis of chiral pharmaceutical intermediates and chiral drugs.
(1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol can be prepared by various methods. One commonly used method is the reaction of diphenylmethyl malonate with lithium (N,N-dimethylglycylamino), followed by hydrolysis to produce the desired product.
Some safety precautions need to be taken when using and handling this compound. It may be irritating and corrosive to the eyes, skin and respiratory tract, so it is recommended to wear appropriate protective measures, such as gloves, goggles and protective clothing. In addition, it should be stored in a dry, cool place and away from fire and oxidizing agents.
Last Update:2024-04-09 20:52:54