Name | 2,4,5-Trimethoxybenzaldehyde |
Synonyms | Gazarin NCI-C61632 ASARALDEHYDE ASARONALDEHYDE Asarylaldehyde Azarylaldehyde 2,4,5-trimethyl ether 2,4,5-TRIMETHOXYBENZALDEHYDE 2,4,5-Trimethoxybenzaldehyde |
CAS | 4460-86-0 |
EINECS | 224-713-3 |
InChI | InChI=1/C10H12O4/c1-12-8-5-10(14-3)9(13-2)4-7(8)6-11/h4-6H,1-3H3 |
InChIKey | IAJBQAYHSQIQRE-UHFFFAOYSA-N |
Molecular Formula | C10H12O4 |
Molar Mass | 196.2 |
Density | 1.2166 (rough estimate) |
Melting Point | 112-114 °C (lit.) |
Boling Point | 140°C 4mm |
Flash Point | 140°C/4mm subl. |
Water Solubility | <0.1 g/100 mL at 22 ºC |
Solubility | Water solubility <0.1g/100 mL (22°C) |
Vapor Presure | 0.000125mmHg at 25°C |
Appearance | White-like crystal |
Color | White to light beige |
BRN | 1951403 |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Sensitive | Air Sensitive |
Refractive Index | 1.5550 (estimate) |
MDL | MFCD00003312 |
Physical and Chemical Properties | Off-white crystals. Melting point 109-112 °c. |
Use | Used as a pharmaceutical intermediate for the preparation of asarone |
In vitro study | Asaraldehyde production is abundant, but not at all in its liquid medium as well as in its natural host, C. kanehirae wood. If cultured with acid-digested sawdust or vanillin from C. kanehirae wood, Asaraldehyde was produced in its medium. 100 mg/ml Asaraldehyde showed 3.32% prostaglandin H endoperoxide synthase -1 (COX-1) inhibitory activity, 52.69% of prostaglandin H endoperoxide synthase -2 (COX-2) inhibitory activity. 100 µg/mL of Asaraldehyde tended to inhibit the COX-2 enzyme. The inhibition ratio of Asaraldehyde to COX-2/COX-1 was 17.68 at 100 µg/mL compared to control. Asaraldehyde down-regulates the expression of C/EBPβ, C/ebpδ and C/EBPα, and inhibits the expression of PPARγ1, PPARγ2 and acetyl-coenzyme A carboxylase (ACC). |
Hazard Symbols | C - Corrosive |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | CU8460000 |
TSCA | Yes |
HS Code | 29124990 |
Raw Materials | 1,4-Benzoquinone |
Reference Show more | 1. Dong Xiaoke, Liu Jinmin, Li Zhonghao, Yuan Siyuan, Wang Kaiyue, Li Lili, Zheng xiangchun. Study on the main blood components and pharmacokinetics of chaibei Zhixian decoction in rats [J]. Global Journal of Traditional Chinese Medicine, 2021,14(03):377-383. |