Molecular Formula | C19H27N7O16P2 |
Molar Mass | 671.41 |
Solubility | H2O: soluble10mg/mL |
Appearance | lyophilized powder |
Storage Condition | −20°C |
In vivo study | Polyinosinic-polycytidylic acid treatment inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Polyinosinic-polycytidylic acid. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | TR0175000 |
Reference Show more | 1. [IF=9.229] Ting He et al."Hyalase-Mediated Cascade Degradation of a Matrix Barrier and Immune Cell Penetration by a Photothermal Microneedle for Efficient Anticancer Therapy."Acs Appl Mater Inter. 2021;13(23):26790–26799 |
Biological activity | Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA, an agonist of TLR3 and retinoic acid inducible gene I receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and alter the microenvironment of tumors, and can also directly trigger apoptosis in cancer cells. |
target | TLR3, RIG-I, MDA5, apoptosis |
Cell Line: | WM793, WM278, WM239A, WM9 and 1205Lu cells 1205Lu cells 1205Lu cells 1205Lu cells |
Concentration: | 20 ng/mL 200 ng/mL 3 ng/mL 5 ng/mL |
Incubation Time: | 24 hours 24 hours 24 hours 24 hours |
Result: | Strongly reduced viability from 100% in controls to 20%–50% within 24 hours. Induced apoptosis in 1205Lu cells. Induced IFN-β expression in melanoma cells. Revealed active subunits of caspase-9 and caspase-8 in melanoma cells. |
Use | A double-stranded homopolymer that can be used as a model RNA for studying cell signal transduction at the TLR3 level. It is also a TRIF-dependent toll-like receptor -3(TLR3) ligand. |